A novel practical synthesis of benzothiazoles via pd-catalyzed thiol cross-coupling
A novel practical synthesis of benzothiazoles via pd-catalyzed thiol cross-coupling
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DOI：
10.1021/ol7015737
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发表时间：
2007-08-30
期刊：
影响因子：
5.2
通讯作者：
Mase, Toshiaki
中科院分区：
文献类型：
--
作者：
Itoh, Takahiro;Mase, Toshiaki
以2-溴苯胺为原料合成了取代苯并噻唑。在钯催化剂的作用下，将不同的2-溴苯胺与烷基硫代酸酯进行高收率反应。得到的硫化物在碱性或酸性条件下通过同时生成硫醇和缩合，很容易转化为相应的苯并噻唑。
A convenient synthesis of substituted benzothiazoles from 2-bromoanilides has been accomplished. The various 2-bromoanilides were reacted with an alkyl thiolate in high yields using a palladium catalyst. The resulting sulfides were easily converted to the corresponding benzothiazoles via the simultaneous generation of thiols and condensation under basic or acidic conditions.