Illness severity, viral shedding, and antibody responses in infants hospitalized with bronchiolitis caused by respiratory syncytial virus
Illness severity, viral shedding, and antibody responses in infants hospitalized with bronchiolitis caused by respiratory syncytial virus
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DOI：
10.1086/339822
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发表时间：
2002-04-15
影响因子：
6.4
通讯作者：
Graham, BS
中科院分区：
文献类型：
--
作者：
Wright, PF;Gruber, WC;Graham, BS
呼吸道合胞病毒（RSV）诱导的毛细支气管炎中宿主因素、病毒脱落、疾病严重程度和抗体应答之间的关系尚不明确。在RSV免疫球蛋白治疗的多中心、双盲、安慰剂对照试验中，对77例因RSV毛细支气管炎住院的婴儿进行了前瞻性评价。疾病严重程度受年龄和宿主危险因素影响，但不受RSV中和抗体滴度或入组时鼻分泌物中病毒量的影响。鼻分泌物中的病毒回收率是可变的，但在入组时最高。入组前的初步诊断、抗体滴度、年龄或急性呼吸道疾病持续时间不影响病毒脱落。在插管患者中，鼻分泌物和气管内吸出物中回收的病毒量高度相关。在64%接受安慰剂的受试者中观察到血清中和抗体应答。应答不受年龄、初步诊断、回收的病毒量或疾病严重程度的影响，但受预先存在的抗体抑制。
The relationships between host factors, viral shedding, illness severity, and antibody response in respiratory syncytial virus (RSV)-induced bronchiolitis are poorly defined. These relationships were prospectively evaluated in 77 infants hospitalized with RSV bronchiolitis in multicenter, double-blind, placebo-controlled trials of RSV immunoglobulin therapy. Severity of illness was influenced by age and host risk factors but was not influenced by RSV neutralizing antibody titer or by the amount of virus in nasal secretions at enrollment. Virus recovery in nasal secretions was variable but was highest at enrollment. Viral shedding was not influenced by primary diagnosis, antibody titer, age, or duration of acute respiratory illness before enrollment. In intubated patients, the amounts of virus recovered in nasal secretions and endotracheal aspirates were highly correlated. A serum neutralizing antibody response was seen in 64% of subjects who received placebo. The response was not influenced by age, primary diagnosis, amount of virus recovered, or severity of illness but was suppressed by preexisting antibody.