Dose responses of five hepatocarcinogens for the initiation of rat hepatocarcinogenesis.
Dose responses of five hepatocarcinogens for the initiation of rat hepatocarcinogenesis.
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DOI：
10.1016/0304-3835(81)90155-5
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发表时间：
1981-12
期刊：
影响因子：
9.7
通讯作者：
K. Imaida;T. Shirai;M. Tatematsu;T. Takano;N. Ito
中科院分区：
文献类型：
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作者：
K. Imaida;T. Shirai;M. Tatematsu;T. Takano;N. Ito
Using the Solt and Farber model (Nature, 263 (1976) 701), dose-response relationships between initiating agents and the induction of hyperplastic nodules in rat liver were investigated. Male Fischer 344 rats were initiated by a single application of 1 of 5 carcinogens at 3 doses: 200.0, 50.0 and 12.5 mg/kg of diethylnitrosamine (DEN); 1.00, 0.25 and 0.062 mg/kg of aflatoxin B1(Af-B1); 60.0, 15.0 and 3.75 mg/kg ofN-2-fluorenylacetamide (2-FAA); 600.0, 150.0 and 37.5 mg/kg of 3′-methyl-4-dimethylaminobenzene (3′-me-DAB); 40.0, 10.0 and 2.5 mg/kg of dimethylnitrosamine (DMN) and their vehicles. Two weeks after initiation, animals were placed on a 0.02% 2-FAA diet for 2 weeks. Partial hepatectomy was performed at the end of the third week of the experiment. All rats were killed 4 weeks after the initiation, and the hyperplastic nodules of the liver were counted and their areas measured.Dose responses were observed in both numbers and areas of hyperplastic nodules per unit area of sections with all of the 5 carcinogens examined.
