Soda and cell aging: associations between sugar-sweetened beverage consumption and leukocyte telomere length in healthy adults from the National Health and Nutrition Examination Surveys.
Soda and cell aging: associations between sugar-sweetened beverage consumption and leukocyte telomere length in healthy adults from the National Health and Nutrition Examination Surveys.
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DOI：
10.2105/ajph.2014.302151
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发表时间：
2014-12
影响因子：
12.7
通讯作者：
Epel ES
中科院分区：
文献类型：
--
作者：
Leung CW;Laraia BA;Needham BL;Rehkopf DH;Adler NE;Lin J;Blackburn EH;Epel ES
我们测试了白细胞端粒长度的维持（健康细胞衰老的基础）是否提供了含糖饮料（SSB）消费与心脏代谢疾病风险之间的联系。我们在全国代表性的健康成年人样本中研究了 SSB、无糖汽水和果汁的摄入量与端粒长度之间的横断面关联。研究人群包括 1999 年至 2002 年国家健康和营养检查调查中的 5,309 名成年人，年龄在 20 岁至 65 岁之间，之前没有糖尿病或心血管疾病史。从 DNA 样本中测定白细胞端粒长度。通过 24 小时饮食回忆来评估饮食。使用多元线性回归检查对数转换端粒长度结果的关联性。调整社会人口统计学和健康相关特征后，饮用含糖汽水与较短的端粒相关（β=-0.010，95% CI -0.020，-0.001，P=0.04）。饮用 100% 果汁与较长端粒略有相关（β= 0.016，95% CI -0.000，0.033）。没有观察到无糖汽水或非碳酸含糖饮料的消耗与端粒长度之间存在显着关联。经常饮用含糖汽水可能会加速细胞老化，从而影响代谢性疾病的发展。
We tested whether leukocyte telomere length maintenance, which underlies healthy cellular aging, provides a link between sugar-sweetened beverage (SSB) consumption and risk of cardiometabolic disease. We examined cross-sectional associations between consumption of SSBs, diet soda and fruit juice and telomere length in a nationally representative sample of healthy adults. The study population included 5,309 adults, aged 20 to 65 years, with no prior history of diabetes or cardiovascular disease, from the 1999–2002 National Health and Nutrition Examination Surveys. Leukocyte telomere length was assayed from DNA specimens. Diet was assessed using 24-hour dietary recalls. Associations were examined using multivariate linear regression for the outcome of log-transformed telomere length. After adjustment for sociodemographic and health-related characteristics, sugar-sweetened soda consumption was associated with shorter telomeres (β=−0.010, 95% CI −0.020, −0.001, P=0.04). Consumption of 100% fruit juice was marginally associated with longer telomeres (β= 0.016, 95% CI −0.000, 0.033). No significant associations were observed between consumption of diet sodas or non-carbonated sugar-sweetened beverages and telomere length. Regular consumption of sugar-sweetened sodas may influence metabolic disease development through accelerated cell aging.