Associations Between Autoimmune Conditions and Gastric Cancer Risk Among Elderly Adults in the United States.

Associations Between Autoimmune Conditions and Gastric Cancer Risk Among Elderly Adults in the United States.
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DOI:
10.14309/ajg.0000000000001622
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发表时间:
2022-03-01
期刊:
The American journal of gastroenterology
影响因子:
--
通讯作者:
Engels EA
Engels EA
中科院分区:
其他
文献类型:
--
作者:
Song M;Camargo MC;Derkach A;Rabkin CS;Engels EA

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Pernicious anemia (PA) is a risk factor for gastric cancer. Other autoimmune conditions may also contribute. In a case-control study, we evaluated 47 autoimmune conditions among 39,125 gastric cancers and 200,000 cancer-free controls. Six conditions were associated with increased gastric cancer risk (range of adjusted odds ratios [ORs]: 1.28-1.93, p<0.05): PA, membranous nephropathy, primary biliary cirrhosis, pure red cell aplasia, primary sclerosing cholangitis, and Graves’ disease. PA was associated with 8 other autoimmune conditions (adjusted ORs: 1.57-4.54, p<0.05). Autoimmune conditions associated with gastric cancer or PA may reflect effects of autoimmune gastritis or other carcinogenic pathways.
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