Influenza Immunization in Low- and Middle-Income Countries: Preparing for Next-Generation Influenza Vaccines
Influenza Immunization in Low- and Middle-Income Countries: Preparing for Next-Generation Influenza Vaccines
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DOI：
10.1093/infdis/jiz024
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发表时间：
2019-04-15
影响因子：
6.4
通讯作者：
Neuzil, Kathleen M.
中科院分区：
文献类型：
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作者：
Ortiz, Justin R.;Neuzil, Kathleen M.
流感疫苗具有长期的安全性和已证实的有效性；然而，它们在低收入和中等收入国家（LMICs）很少使用。尽管疫苗使用不足的原因是多方面的，而且因国而异，但每年最多需要两次重新配制疫苗和每年接种疫苗是中低收入国家预防流感的障碍。目前正在进行重大努力，生产下一代流感疫苗，以提供持久的保护，防止病毒漂移，这种疫苗可以解决这些未得到满足的需求。然而，需要更多的信息来影响大多数低收入和中等收入国家的免疫政策。需要更好地估计疫苗对重要公共卫生结果的影响，提供负担得起的疫苗，改进规划适用性，加强免疫接种基础设施，如果要在中低收入国家实现广泛采用，就必须在开发新疫苗的早期阶段加以考虑。
Influenza vaccines have a long history of safety and demonstrated efficacy; however, they are seldom used in low-and middle-income countries (LMICs). Although reasons for underuse are multifactorial and differ from country to country, the need for up to twice-annual reformulation and yearly vaccination are obstacles to influenza prevention in LMICs. Major efforts are underway to produce next-generation influenza vaccines that provide durable protection against drifted strains, and such vaccines could address these unmet needs. However, additional information is required to influence immunization policies in most LMICs. Better estimates of vaccine impact on important public health outcomes, more affordable vaccines, improved programmatic suitability, and strengthened immunization delivery infrastructures are needed and must be considered early during the development of new vaccines if widespread adoption in LMICs is to be achieved.