BIOACTIVE COMPOUNDS FROM AQUATIC AND TERRESTRIAL SOURCES
BIOACTIVE COMPOUNDS FROM AQUATIC AND TERRESTRIAL SOURCES
复制标题
DOI：
10.1021/np50070a001
复制
发表时间：
1990-07-01
影响因子：
5.1
通讯作者：
GADE, G
中科院分区：
文献类型：
--
作者：
RINEHART, KL;HOLT, TG;GADE, G
自然界为化学家提供了一系列永无休止的令人着迷的问题。然而，许多最令人感兴趣的问题都涉及数量极少的化合物。一种解决方案是专注于生物测定引导的分离。通过这样做，人们可以从几乎任何门中分离出具有新颖结构或未知活性的化合物，包括被囊动物、海绵、昆虫，甚至是经过大量研究的陆生植物，正如我们实验室最近的几项研究所例证的那样，这些研究涉及从抗病毒和抗菌活性到细胞毒性和免疫调节等活动。此外，更新的光谱技术，特别是快原子轰击质谱法和串联质谱法，增强了研究微量化合物的能力，包括对宿主生物体重要的化合物，例如昆虫或海洋无脊椎动物中的神经肽。
The world of nature provides a never-ending set of fascinating problems for the chemist. Many of the most intriguing problems, however, concern compounds available in only truly minute quantities. One solution is to focus on bioassay-guided separations. In so doing one can isolate compounds with novel structures or unsuspected activities from almost any phylum, including tunicates, sponges, insects, or even the much-studied terrestrial plants, as exemplified in several recent studies in our laboratory involving activities ranging from antiviral and antimicrobial activity to cytotoxicity and immunomodulation. Moreover, newer spectroscopic techniques, especially fast atom bombardment mass spectrometry and tandem mass spectrometry, enhance one''s ability to study compounds present in minute quantities, including those of importance to the host organism, such as neuropeptides in insects or marine invertebrates.