Spontaneous transfer of lipids between membranes.
Spontaneous transfer of lipids between membranes.
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脂质在膜之间的自发转移。
DOI：
10.1007/978-1-4899-1621-1_11
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发表时间：
1990
影响因子：
--
通讯作者：
Brown,RE
中科院分区：
文献类型：
--
作者：
Brown,RE
多年前首次观察到不同生物表面之间的脂质转移（Hahn 和 Hevesy，1939a，b；Hagerman 和 Gould，1951）。自这些早期观察以来，已经识别出几种不同类型的脂质转移：（1）由可溶性蛋白质介导的脂质转移； (2) 由于囊泡从一层膜出芽随后与目标膜融合而导致的脂质转移； (3)通过脂质单体通过水介质扩散或通过囊泡间碰撞后的瞬时接触自发发生的脂质转移。尽管 (1) 和 (2) 型已成为多项综述的主题（Spener 和 Wirtz，1985；Wirtzet al.，1986；Helmkamp，1986；Sleight，1987；Dawidowicz，1987a），但对自发脂质转移的关注却少之又少。在最近讨论自发脂质转移的评论中，报道通常集中在胆固醇和/或磷脂上（Lange，1986；Sleight，1987；Dawidowicz，1987b；Phillips 等，1987）。本综述将主要致力于膜之间发生的自发脂质转移，并将包括几种不同的脂质。
Lipid transfer between different biological surfaces was first observed many years ago (Hahn and Hevesy, 1939a,b; Hagerman and Gould, 1951). Since those early observations, several different types of lipid transfer have been discerned: (1) lipid transfer mediated by soluble proteins; (2) lipid transfer due to vesicle budding from one membrane followed by fusion with a target membrane; and (3) lipid transfer that occurs spontaneously either by lipid monomer diffusion through the aqueous medium or by transient contact following intervesicular collisions. Although types (1) and (2) have been the subject of several reviews (Spener and Wirtz, 1985; Wirtzet al., 1986; Helmkamp, 1986; Sleight, 1987; Dawidowicz, 1987a), far less attention has been devoted to spontaneous lipid transfer. In the recent reviews in which spontaneous lipid transfer has been discussed, the coverage usually has been focused on cholesterol and/or phospholipids (Lange, 1986; Sleight, 1987; Dawidowicz, 1987b; Phillips et al., 1987). This review will be devoted primarily to spontaneous lipid transfer as it occurs between membranes and will include several different lipids.