Non-Exercise Estimated Cardiorespiratory Fitness: Associations with Brain Structure, Cognition, and Memory Complaints in Older Adults.
Non-Exercise Estimated Cardiorespiratory Fitness: Associations with Brain Structure, Cognition, and Memory Complaints in Older Adults.
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DOI：
10.1016/j.mhpa.2011.01.001
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发表时间：
2011-06-01
影响因子：
4.7
通讯作者：
Kramer, Arthur F
中科院分区：
文献类型：
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作者：
McAuley, Edward;Szabo, Amanda N;Kramer, Arthur F
越来越多的证据表明，心肺健康(CRF)与大脑结构和功能有关，通过运动训练改善CRF与老年人的神经和认知功能有关。这项研究的目的是验证CRF的非运动估计的使用，并检查其与认知功能、大脑结构和主观记忆主诉的关系。低活动量的老年人(N=86；男性=65.14)完成了医生指导的最大运动测试、1英里的定时步行、几项认知功能测量和3Tesla结构磁共振成像。健身也是根据Jurca等人(Jurca et al.，2005)根据年龄、性别、体重指数、静息心率和自我报告的体力活动水平得出的公式计算得出的。分析表明，CRF的所有三个指标彼此之间存在显著的相关性。此外，认知功能、海马体体积和记忆抱怨的测量与每一种健康测量都显著相关。这些发现对于使用低风险、低成本、非运动的CRF估计来确定健康与老年人大脑结构和认知功能的关系具有一定的意义。因此，这一措施可能对更大范围的基于人群的研究有用。还需要进一步的验证，以及确定这种关系在运动干预过程中是否成立。
There is increasing evidence that cardiorespiratory fitness (CRF) is associated with brain structure and function, and improvements in CRF through exercise training have been associated with neural and cognitive functioning in older adults. The objectives of this study were to validate the use of a non-exercise estimate of CRF, and to examine its association with cognitive function, brain structure and subjective memory complaints. Low active, older adults (N = 86; M age= 65.14) completed a physician-supervised maximal exercise test, a 1-mile timed walk, several measures of cognitive function, and a 3 Tesla structural MRI. Fitness was also calculated from an equation derived by (Jurca et al., 2005) based on age, sex, body mass index, resting heart rate, and self-reported physical activity level. Analyses indicated that all three measures of CRF were significantly correlated with one another. In addition, measures of cognitive function, hippocampus volume, and memory complaints were significantly correlated with each measure of fitness. These findings have implications for using a low-risk, low-cost, non-exercise estimate of CRF in determining fitness associations with brain structure and cognitive function in older adults. As such, this measure may have utility for larger population based studies. Further validation is required, as is determination of whether such relationships hold over the course of exercise interventions.