Bimanual co-ordination in Parkinson's disease
Bimanual co-ordination in Parkinson's disease
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DOI：
10.1093/brain/121.4.743
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发表时间：
1998-04-01
期刊：
影响因子：
14.5
通讯作者：
Rogers, MA
中科院分区：
文献类型：
--
作者：
Johnson, KA;Cunnington, R;Rogers, MA
基底神经节可能参与双手协调。临床报道帕金森病（损害基底神经节输出）会导致协调双手运动困难。然而，任何双手协调困难都可能是特定于任务的，因为实验观察结果是模棱两可的。为了推断基底神经节在协调两臂方面的作用，本研究调查了帕金森病患者的双手协调能力。十六名帕金森病患者和匹配的对照受试者以不同的速度（1 和 2 Hz）和相位关系执行双手启动任务。所有受试者都在一对曲柄上以快（2 Hz）和慢（1 Hz）的速度进行所需的双手同相运动。然而，帕金森病患者无法进行不对称的反相运动，即曲柄的旋转在任一速度下相差 180 度；而是恢复到同相对称运动。对于帕金森病患者，使用外部计时提示时，同相运动的表现更加准确和稳定；然而，对于反相运动，外部提示加剧了患者恢复到更对称的同相运动的倾向。
The basal ganglia may be involved in bimanual co-ordination. Parkinson's disease (which impairs basal ganglia output) is clinically reported to cause difficulties in the performance of co-ordinated bimanual movements. Nevertheless, any bimanual co-ordination difficulties may be task specific, as experimental observations are equivocal. To infer the role of the basal ganglia in co-ordinating the two arms, this study investigated the bimanual co-ordination of patients with Parkinson's disease. Sixteen Parkinson's disease patients and matched control subjects performed a bimanual cranking task, at different speeds (1 and 2 Hz) and phase relationships. All subjects performed the required bimanual in-phase movement on a pair of cranks, at fast (2 Hz) and slow (1 Hz) speeds. However the Parkinson's disease patients were unable to perform the asymmetrical anti-phase movement, in which rotation of the cranks differed by 180 degrees, at either speed; but instead reverted to the in-phase symmetrical movement. For Parkinson's disease patients, performance of the in-phase movement was more accurate and stable when an external timing cue was used; however for anti-phase movement, the external cue accentuated the tendency for patients to revert to more symmetrical, in-phase movements.