Cytokines are associated with longitudinal changes in cognitive performance among urban adults
Cytokines are associated with longitudinal changes in cognitive performance among urban adults
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DOI：
10.1016/j.bbi.2019.04.027
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发表时间：
2019-08-01
影响因子：
15.1
通讯作者：
Zonderman, Alan B.
中科院分区：
文献类型：
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作者：
Beydoun, May A.;Weiss, Jordan;Zonderman, Alan B.
工作背景：慢性全身性炎症与代表阿尔茨海默病（AD）和认知能力下降的早期标志物的结构和功能性脑变化正相关。目前的研究探讨了非裔美国人和白人城市成年人的全身炎症和认知能力之间的关系。方法：参与者选自健康老龄化在整个生命周期的多样性社区（HANDLS）研究（2004 - 2013年，基线年龄：30 - 64岁，平均+/-SD随访时间为4.64 +/-0.93岁，N = 189 - 222，k = 1.5 - 1.7次观察/受试者）。对已知与AD发病率呈正相关的细胞因子进行横向和纵向认知功能测试，按年龄组（50岁）、性别和种族分层。进行了一系列混合效应回归模型，调整了关键混杂因素。在关键发现中，在老年人中，IL 1 β与执行功能测试的更快下降率呈正相关（年龄> 50岁，γ（11）=+2.49 +/-0.89，p = 0.005），而在总人群中，IL-6与语言记忆测试中的快速下降有关（γ（11）=-0.011 +/-0.004，p = 0.009）。在较年轻的参与者中，IL-18与基线时注意力测试的较差表现有关（年龄50岁，γ（11）=+0.0010 +/-0.0004，p = 0.008）。最后，在白人中，不像非洲裔美国人，IL-6与更好的基线性能的两个测试的口头和工作memory.Conclusions：细胞因子与年龄相关的认知能力下降的中年和老年城市成年人的年龄组和种族特异性的方式。需要进一步的纵向研究来复制我们的研究结果，还需要研究通过相关的生物和心理社会因素进行调解。
Background: Chronic systemic inflammation has been positively associated with structural and functional brain changes representing early markers of Alzheimer's Disease (AD) and cognitive decline. The current study examined associations between systemic inflammation and cognitive performance among African-Americans and Whites urban adults.Methods: Participants were selected from the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study (2004-2013, baseline age: 30-64 y, mean +/- SD follow-up time of 4.64 +/- 0.93 y, N = 189-222, k = 1.5-1.7 observations/participant). Cytokines known to be positively linked to AD incidence among others were tested against cross-sectional and longitudinal cognitive function, stratifying by age group ( 50 y), sex and race. A series of mixed-effects regression models were conducted, adjusting for key confounders.Results: Among key findings, IL1 beta was positively associated with a faster rate of decline on a test of executive functioning, among older adults (age > 50 y, gamma(11) = + 2.49 +/- 0.89, p = 0.005), while in the total population, IL -6 was linked to a faster decline on a test of verbal memory (gamma(11) = -0.011 +/- 0.004, p = 0.009). Among younger participants, IL -18 was linked to a poorer performance on a test of attention at baseline (age 50 y, gamma(11) = + 0.0010 +/- 0.0004, p = 0.008). Finally, among Whites, unlike among African -Americans, IL-6 was associated with a better baseline performance on two tests of verbal and working memory.Conclusions: Cytokines were shown to be associated with age-related cognitive decline among middle-aged and older urban adults in an age group and race-specific manner. Further longitudinal studies are needed to replicate our findings and mediation through relevant biological and psychosocial factors need to be studied as well.