Distinct neural correlates for attention lapses in patients with schizophrenia and healthy participants.
Distinct neural correlates for attention lapses in patients with schizophrenia and healthy participants.
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DOI：
10.3389/fnhum.2015.00502
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发表时间：
2015
影响因子：
2.9
通讯作者：
Carter CS
中科院分区：
文献类型：
--
作者：
Phillips RC;Salo T;Carter CS
在健康人群中，短暂的注意力疏忽是很常见的。这一现象最近得到了越来越多的研究，特别是与默认模式网络(DMN)有关的研究。以前的研究表明，这些失误可能是由于干扰任务无关的想法造成的。精神分裂症的这一现象的特征是包括注意力缺陷在内的各种认知缺陷，以前还没有人探索过这一现象。我们使用AX持续操作任务来调查健康参与者和精神分裂症患者的注意力疏忽。我们发现这两组人之间存在不同的网络激活模式。健康受试者的失误与DMN的激活有关，而在患者中，同样的行为现象与额顶控制网络(FPCN)区域的失活有关。与在健康参与者中观察到的结果相比，这些结果表明，患者注意力疏忽的另一个原因是失去了与任务相关的背景，而不是侵入性的与任务无关的想法。
Momentary lapses in attention are common in healthy populations. This phenomenon has recently received increased investigation, particularly in relationship to the default mode network (DMN). Previous research has suggested that these lapses may be due to intrusive task-irrelevant thoughts. The study of this phenomenon in schizophrenia, which is characterized by a wide variety of cognitive deficits including deficits in attention, has not previously been explored. We used the AX Continuous Performance Task to investigate attention lapses in healthy participants as well as patients with schizophrenia. We found distinct patterns of network activation between these two groups. Lapses in healthy participants were associated with DMN activation, while in patients, the same behavioral phenomenon was associated with deactivations in frontal-parietal control network (FPCN) regions. When considered in contrast to the results observed in healthy participants, these results suggest an additional origin of attention lapses in patients derived from a loss of task-related context, rather than intrusive task-irrelevant thoughts.