Magnetization reversal and specific loss power of magnetic nanoparticles in cellular environment evaluated by AC hysteresis measurement
Magnetization reversal and specific loss power of magnetic nanoparticles in cellular environment evaluated by AC hysteresis measurement
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DOI：
10.1155/2015/836761
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发表时间：
2015
影响因子：
--
通讯作者：
S. Ota;Tsutomu Yamada;Y. Takemura
中科院分区：
文献类型：
--
作者：
S. Ota;Tsutomu Yamada;Y. Takemura
利用理论模型对磁性纳米粒子（MNP）诱导的细胞内热疗效应进行了评价。在这项研究中，磁化反转的MNP在细胞环境下的AC磁场进行了评估的基础上测得的AC磁滞回线。特定的和固有的损失功率-SLP和ILP-也估计从交流磁滞回线的面积。测量的样品是分散在水中的液体样品、与环氧键混合的固定样品和细胞样品。在细胞环境中，粒子的旋转和磁矩被抑制的粒子细胞和偶极-偶极相互作用，分别。MNP在细胞环境中的散热低于液体和固定样品的散热。此外，估计了单个细胞中的SLP。根据传统的理论模型和单电池中测量的SLP计算了单电池的温升。
The effect of intracellular hyperthermia induced by magnetic nanoparticles (MNPs) has been evaluated using a theoretical model. In this study, magnetization reversal of MNPs in the cellular environment under an AC magnetic field was evaluated on the basis of measured AC hysteresis loops. The specific and intrinsic loss powers--SLP and ILP--were also estimated from the area of AC hysteresis loops. The measured samples were a liquid sample dispersed in water, a fixed sample mixed with an epoxy bond, and a cellular sample. In the cellular environment, the rotations of particles and magnetic moments were inhibited by particle-cell and dipole-dipole interactions, respectively. The heat dissipation of the MNPs in the cellular environment was lower than that of the liquid and fixed samples. Moreover, the SLP in a single cell was estimated. The temperature increase of a single cell was calculated on the basis of the conventional theoretical model and the SLP measured in a single cell.