Interfacial effect of molecules on nucleation kinetics
Interfacial effect of molecules on nucleation kinetics
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DOI：
10.1021/jp010671z
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发表时间：
2001-11-29
影响因子：
3.3
通讯作者：
Liu, XY
中科院分区：
文献类型：
--
作者：
Liu, XY
首次系统地研究了对乙酰氨基酚成核动力学的界面效应。这些效应可分为（a）界面成核势垒降低效应，由所谓的界面相关参数f（m，R '）描述;和（B）扭结积分效应，由扭结动力学系数β（扭结）描述。第二种效应包括添加剂或杂质从胚胎表面吸附位置的去溶剂化效应，以及在基底-流体界面诱导的液体预有序化。添加剂间乙酰氨基苯酚和对乙酰氧基乙酰苯胺通过吸附在对乙酰氨基酚的表面上抑制对乙酰氨基酚成核，这抑制了界面外延效应（成核势垒降低效应）（f（m，R '）-> 1）并提高了去溶剂化能垒（β（扭结）-> 0），而对羟基苯甲酸甲酯仅通过略微提高去溶剂化能垒来抑制对乙酰氨基酚成核。在溶液中形成菌株的多糖将根据诱导的液体分子的预排序促进成核。这种界面诱导的预有序效应是本文首次发现的，不同于经典的外延效应。这种效应原则上可以用来设计复杂材料的微米和纳米结构。
Interfacial effects of molecules on nucleation kinetics of paracetamol were systematically examined for the first time. The effects can be classified into (a) the interfacial nucleation barrier lowering effects, described by a so-called interfacial correlation parameter, f(m,R'); and (b) the kink integration effect, described by kink kinetic coefficient beta (kink). The second effect includes that the effect of desolvation of additives or impurities from the adsorption sites of embryo surface, and the induced pre-ordering of liquid at the substrate-fluid interface. Additives m-acetamidophenol and p-acetoxyacetanilide inhibit paracetamol nucleation by adsorbing on the surface of paracetamol, which suppresses the interface epitaxial effect (the nucleation barrier lowering effect) (f(m,R') --> 1) and enhancing the desolvation energy barrier (beta (kink) --> 0), whereas p-hydroxybenzoic acid methyl ester only inhibits paracetamol nucleation by enhancing slightly the desolvation energy barrier. Polysaccharide, which forms strains in the solution, will promote nucleation in terms of the induced preordering of liquid molecules. This interface induced pre-ordering effect, identified first time in this work, is different from the classic epitaxial effect. This effect can in principle be utilized to engineer the micro-and nano structure of complex materials.