GDNF mRNA in Schwann cells and DRG satellite cells after chronic sciatic nerve injury
GDNF mRNA in Schwann cells and DRG satellite cells after chronic sciatic nerve injury
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DOI：
10.1097/00001756-199603220-00004
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发表时间：
1996-03-22
期刊：
影响因子：
1.7
通讯作者：
Fried, K
中科院分区：
文献类型：
--
作者：
Hammarberg, H;Piehl, F;Fried, K
神经胶质细胞系来源的神经营养因子（GDNF）对不同类型的神经元，包括胎儿运动神经元和胚胎感觉神经节神经元，均表现出神经营养特性。我们证明，成年大鼠坐骨神经慢性损伤诱导损伤部位近端和远端雪旺细胞中GDNF mRNA表达快速上调，并且该mRNA表达在损伤后至少5个月保持高水平。此外，GDNF mRNA在受影响的L4/L5 DRGs的卫星细胞和雪旺细胞中升高并保持高水平。这些发现表明，GDNF是成人慢性初级感觉神经元损伤后事件的重要因素，也可能是成人运动神经元轴切术后事件的重要因素。
GLIAL cell line-derived neurotrophic factor (GDNF) exhibits neurotrophic properties on different types of neurones, including fetal motoneurones and embryonic neurones of sensory ganglia. We demonstrate that chronic injury to the adult rat sciatic nerve induces a rapid up-regulation of GDNF mRNA expression in Schwann cells proximal as well as distal to the injury site, and that expression of this mRNA remains at high levels for at least 5 months after injury. In addition, GDNF mRNA increases and remains high in satellite cells and Schwann cells of the affected L4/L5 DRGs. These findings suggest that GDNF is an important factor in the events that follow upon adult chronic primary sensory neurone injury, and possibly also after adult motoneurone axotomy.