Movement Patterns of Small Rodents in Lassa Fever-Endemic Villages in Guinea
Movement Patterns of Small Rodents in Lassa Fever-Endemic Villages in Guinea
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DOI：
10.1007/s10393-018-1331-8
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发表时间：
2018-06-01
期刊：
影响因子：
2.5
通讯作者：
Fichet-Calvet, Elisabeth
中科院分区：
文献类型：
--
作者：
Marien, Joachim;Kourouma, Fode;Fichet-Calvet, Elisabeth
纳塔尔多乳鼠（Mastomys natalensis）是拉沙沙粒病毒的储存宿主，拉沙沙粒病毒是人类拉沙热的病原体。由于没有供人类使用的疫苗，啮齿动物控制和调整人类行为目前被认为是控制拉沙热的唯一选择。为了制定有效的啮齿动物控制计划，需要更多关于宿主生态的信息。在这项研究中，我们研究了M。在上几内亚拉沙热流行的村庄进行的两次捕获-标记-再捕获和四次染色诱饵（罗丹明B）实验中，观察了natalensis和其他小型啮齿动物的情况。在捕获-标记-再捕获研究中，23%的再捕获M。natalensis在房屋和附近的田地之间移动。而M.在整个研究网格（2 ha）中发现了natalensis，其他啮齿动物物种（Praomys daltoni，Praomys rostratus，Lenniscomys striatus，Mus spp.）大多数被困在周围的田地里对于所有啮齿动物物种，重新捕获之间的距离从未超过100米。在染饵试验中，11%的M. natalensis和41%的P. daltoni从田野迁移到房屋。我们得出结论，M.S. M.在几内亚，natalensis很容易在房屋和附近的田地之间移动。因此，我们认为偶尔消灭家鼠是减少拉沙病毒对人类传播风险的不可持续的方法，因为M。natalensis可能会从啮齿动物未得到控制的田地迅速重新侵入房屋。将永久性灭鼠与其他控制策略（例如，使房屋防鼠或吸引捕食者）可能对拉沙热控制更有效，但必须进一步调查。
The Natal multimammate mouse (Mastomys natalensis) is the reservoir host of Lassa arenavirus, the etiological agent of Lassa fever in humans. Because there exists no vaccine for human use, rodent control and adjusting human behavior are currently considered to be the only options for Lassa fever control. In order to develop efficient rodent control programs, more information about the host's ecology is needed. In this study, we investigated the spatial behavior of M. natalensis and other small rodents in two capture-mark-recapture and four dyed bait (Rhodamine B) experiments in Lassa fever-endemic villages in Upper Guinea. During the capture-mark-recapture studies, 23% of the recaptured M. natalensis moved between the houses and proximate fields. While M. natalensis was found over the entire study grid (2ha), other rodent species (Praomys daltoni, Praomys rostratus, Lemniscomys striatus, Mus spp.) were mostly trapped in the surrounding fields. Distances between recapture occasions never exceeded 100m for all rodent species. During the dyed bait experiments, 11% of M. natalensis and 41% of P. daltoni moved from the fields to houses. We conclude that commensal M. natalensis easily moves between houses and proximate fields in Guinea. We therefore consider occasional domestic rodent elimination to be an unsustainable approach to reduce Lassa virus transmission risk to humans, as M. natalensis is likely to reinvade houses quickly from fields in which rodents are not controlled. A combination of permanent rodent elimination with other control strategies (e.g., make houses rodent proof or attract predators) could be more effective for Lassa fever control, but must be further investigated.