Role of Rap2 and its Downstream Effectors in Tumorigenesis
Role of Rap2 and its Downstream Effectors in Tumorigenesis
复制标题
Rap2 及其下游效应器在肿瘤发生中的作用。
DOI：
10.2174/1871520615666150518092840
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发表时间：
2015-01-01
影响因子：
2.8
通讯作者：
Zheng, Junnian
中科院分区：
文献类型：
--
作者：
Huang, Hui;Di, Jiehui;Zheng, Junnian
Rap2是gtp结合蛋白的一员，在许多类型的肿瘤中被广泛上调。Rap2的特异性效应物可以影响多种癌症相关的细胞过程，包括细胞骨架重组、增殖、迁移和炎症。然而，Rap2在肿瘤发生中的功能作用以及不同效应物之间的相互作用仍有待充分阐明。更全面地了解Rap2的癌症相关信号网络有望促进针对Rap2的癌症治疗药物的发现。本文主要综述了Rap2及其效应物之间的功能和物理相互作用的最新研究进展。我们还推测了这些途径与肿瘤发生的相关性。
Rap2, a member of the GTP-binding proteins, is widely upregulated in many types of tumors. The specific effectors of Rap2 can affect multiple cancer-associated cellular processes, including cytoskeleton reorganization, proliferation, migration, and inflammation. However, the functional role of Rap2 in tumorigenesis and the interplay between different effectors remain to be fully elucidated. A more thorough understanding of the cancer-associated signaling networks of Rap2 is expected to facilitate drug discovery targeting Rap2 for cancer therapy. The present review mainly focused on recent studies on the functional and physical interactions between Rap2 and its effectors. We also speculated on the relevance of these pathways to tumorigenesis.