"886-84-like" tick-borne encephalitis virus strains: Intraspecific status elucidated by comparative genomics
"886-84-like" tick-borne encephalitis virus strains: Intraspecific status elucidated by comparative genomics
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DOI：
10.1016/j.ttbdis.2019.06.006
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发表时间：
2019-08-01
影响因子：
3.2
通讯作者：
Balakhonov, Sergey V.
中科院分区：
文献类型：
--
作者：
Adelshin, Renat V.;Sidorova, Elena A.;Balakhonov, Sergey V.
蜱传脑炎病毒（TBEV）可引起严重的脑膜炎、脑炎和脑膜脑炎。TBEV是一种具有高度人畜共患病潜力的病原体，是一种新兴的全球威胁。TBEV有三种亚型：远东型、西伯利亚型和欧洲型。自2001年以来，有人建议可以区分两种新的亚型：“178-79”和“886-84”。这些假设基于包膜基因片段测序（Zlobin et al. 2001; Kovalev and Mukhacheva，2017）和基因型特异性探针分子杂交（Demina et al. 2010）的结果。在GenBank中，“178-79”株只有一个全基因组序列，“886-84”株有两个完全相同的全基因组序列。为了阐明“886-84样”菌株群的种内位置，我们对分离自东西伯利亚的6个先前未知的“886 -84样”菌株进行了完全测序。应用不同的生物信息学方法，我们可以确定“886-84样”毒株群是TBEV的一个独特亚型。
Tick-borne encephalitis virus (TBEV) can cause severe meningitis, encephalitis, and meningoencephalitis. TBEV represents a pathogen of high zoonotic potential and an emerging global threat. There are three known subtypes of TBEV: Far-Eastern, Siberian and European. Since 2001 there have been suggestions that two new subtypes may be distinguished: "178-79" and "886-84". These assumptions are based on the results of the envelope gene fragment sequencing (Zlobin et al. 2001; Kovalev and Mukhacheva, 2017) and genotype-specific probes molecular hybridization (Demina et al. 2010). There is only one full-genome sequence of "178-79" strain and two identical ones of "886-84" strain can be found in GenBank. For clarification of the intraspecific position of the "886-84-like strains group we completely sequenced six previously unknown "886-84-like" strains isolated in Eastern Siberia. As a result of applying different bioinformatics approaches, we can confirm that "886-84-like" strains group is a distinct subtype of TBEV.