Genetic and environmental causes of variation in basal levels of blood cells.
Genetic and environmental causes of variation in basal levels of blood cells.
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DOI：
10.1375/136905299320565735
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发表时间：
1999-12-01
期刊：
影响因子：
--
通讯作者：
Martin, N G
中科院分区：
文献类型：
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作者：
Evans, D M;Frazer, I H;Martin, N G
在392对12岁的双胞胎中研究了血细胞大小和数量变化的遗传和环境决定因素。测量以下血细胞指数：血红蛋白、红细胞计数、红细胞压积、平均红细胞体积、血小板数量、总白色细胞计数、中性粒细胞水平、单核细胞、嗜酸性粒细胞、总淋巴细胞、CD 3+淋巴细胞、CD 4+淋巴细胞、CD 8+淋巴细胞、CD 19+淋巴细胞、CD 56+淋巴细胞和CD 4 +/CD 8+比值。遗传因素对所有血细胞指标的影响显着，占方差的61%至96%。遗传力估计没有显着差异，男性和女性之间，虽然本研究的样本量不足以排除性别限制基因表达的可能性。常见的环境因素在确定红细胞计数和红细胞压积方面很重要，但在确定任何白色血细胞类型的基础水平方面并不重要。
The genetic and environmental determinants of variation in blood cell size and number were investigated in 392 pairs of 12-year-old twins. The following blood cell indices were measured: haemoglobin, red blood cell count, haematocrit, mean corpuscular volume, platelet number, total white cell count, level of neutrophils, monocytes, eosinophils, total lymphocytes, CD3+ lymphocytes, CD4+ lymphocytes, CD8+ lymphocytes, CD19+ lymphocytes, CD56+ lymphocytes and CD4+/CD8+ ratio. Genetic factors contributed significantly to all blood cell measures accounting for between 61 and 96% of variance. Heritability estimates did not differ significantly between males and females, although the sample size of the present study was not large enough to exclude the possibility of sex-limited gene expression. Common environmental factors were important in determining red blood cell count and haematocrit, but were not important in determining basal levels of any white blood cell type.