Contrasting grooming phenotypes in C57Bl/6 and 129S1/SvImJ mice
Contrasting grooming phenotypes in C57Bl/6 and 129S1/SvImJ mice
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DOI：
10.1016/j.brainres.2004.09.001
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发表时间：
2004-11-26
期刊：
影响因子：
2.9
通讯作者：
Tuohimaa, P
中科院分区：
文献类型：
--
作者：
Kalueff, AV;Tuohimaa, P
由于C57和129小鼠是常用的背景品系，因此更好地了解它们的所有行为特征在神经科学研究中很重要。在啮齿动物的行为中，梳理毛发是一个复杂而基本的仪式，通常是在头尾的过程中进行的(爪子-鼻子-脸-身体腿-尾巴和生殖器)。据报道，各种应激源以及遗传操作都会改变小鼠的毛发及其模式，这表明详细分析毛发行为的重要性。尽管在许多研究中已经评估了C5713L/6和129S1/SvImJ亚株之间的菌株差异，但还没有对它们的梳理进行行为学分析。在这里，我们展示了这些小鼠在自发(新奇诱导)和人工(水诱导)梳理方面的品系差异。总体而言，129S1/SvImJ小鼠在两个测试中都表现出较少的梳理活动，更多的中断和不完整的回合，以及更多不正确的模式转换(与头尾规则相反)，并伴随着较低的垂直活动和较高的排便/排尿。这些结果与129S1/SvImJ小鼠的一般低活动焦虑表型相一致，并表明对小鼠梳理的行为学分析可用于神经行为应激研究，包括突变小鼠和背景小鼠的行为表型。(C)2004爱思唯尔B.V.保留所有权利。
Since C57 and 129 mice are the commonly used background strains, a better knowledge of all their behavioural characteristics is important in neuroscience research. Grooming is a complex and essential ritual in the rodent behavioural repertoire, normally proceeding in a cephalocaudal progression (paws-nose-face-body legs-tail and genitals). Various stressors as well as genetic manipulations have been reported to alter mouse grooming and its patterning, underlying the importance of analysis of grooming behaviours in detail. Although strain differences between C5713L/6 and 129S1/SvImJ substrains have been assessed in many studies, no ethological analyses of their grooming have been performed. Here we show strain differences between these mice in spontaneous (novelty-induced) and artificial (water-induced) grooming. Overall, 129S1/SvImJ mice demonstrated less grooming activity, more interrupted and incomplete bouts, and more incorrect transitions (contrary to the cephalocaudal rule) between patterns, accompanied by lower vertical activity and higher defecation/urination in both tests. These results are consistent with general hypoactive anxious phenotype in 129S1/SvImJ mice and suggest that ethological analysis of mouse grooming may be used in neurobehavioural stress research, including behavioural phenotyping of both mutant and background mice. (C) 2004 Elsevier B.V. All rights reserved.