MULTIPLE SPECIFIC CONTACTS BETWEEN A MAMMALIAN TRANSCRIPTION FACTOR AND ITS COGNATE PROMOTERS
MULTIPLE SPECIFIC CONTACTS BETWEEN A MAMMALIAN TRANSCRIPTION FACTOR AND ITS COGNATE PROMOTERS
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DOI：
10.1038/312409a0
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发表时间：
1984-01-01
期刊：
影响因子：
64.8
通讯作者：
TJIAN, R
中科院分区：
文献类型：
--
作者：
GIDONI, D;DYNAN, WS;TJIAN, R
人转录因子Sp1结合某些病毒和细胞启动子的上游，并激活RNA聚合酶II从这些启动子开始合成RNA。SV-40的Sp1结合位点和一个相关的猴启动子包含多个序列gggggg拷贝，其中3或4个序列与Sp1形成密切接触。聚集的接触落在DNA的一条链上，并在两个启动子的DNA螺旋的主槽中相似地排列。
The human transcription factor Sp1 binds upstream of certain viral and cellular promoters and activates initiation of RNA synthesis from these promoters by RNA polymerase II. The Sp1 binding sites of SV-40 and a related monkey promoter contain multiple copies of the sequence GGGCGG, 3 or 4 of these sequences forming close contacts with Sp1. The clustered contacts fall on 1 strand of the DNA and are arranged similarly in the major groove of the DNA helix in both promoters.