Electric axon guidance in embryonic retina: Galvanotropism revisited
Electric axon guidance in embryonic retina: Galvanotropism revisited
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DOI：
10.1016/j.bbrc.2012.12.115
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发表时间：
2013-02-08
影响因子：
3.1
通讯作者：
Yamashita, Masayuki
中科院分区：
文献类型：
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作者：
Yamashita, Masayuki
除了众所周知的化学引导机制之外，神经系统中生长的轴突在被称为向电性的过程中由细胞外电场引导。早在1920年就首次证实了体外神经细胞的亲电行为。然而，胚胎神经组织是否产生类似的电场来引导轴突生长仍然是未知的。目前的研究表明，细胞外电压梯度存在于胚胎视网膜，这种梯度引导新生视网膜神经节细胞的轴突向他们的目标。这些研究结果表明，在轴突的初始方向，延伸了很长的距离，并提供深入了解胚胎大脑中的发育轴突的适当扩展的机制的重要作用，向电流性。(C)2013 Elsevier Inc. All rights reserved.
In addition to well-known mechanisms of chemical guidance, growing axons in the nervous system are directed by an extracellular electric field in a process known as galvanotropism. The galvanotropic behavior of nerve cells in vitro was first demonstrated as long ago as 1920. However, it remains unknown whether embryonic nerve tissues generate a similar electric field in order to guide growing axons. The present study reveals that an extracellular voltage gradient exists in the embryonic retina and that this gradient guides the axons of newborn retinal ganglion cells towards their targets. These findings indicate an important role for galvanotropism in the initial orientation of axons that extend over long distances, and provide insight into the mechanisms underlying the proper extension of developing axons in the embryonic brain. (C) 2013 Elsevier Inc. All rights reserved.