Changes in temporal acuity with age and with hearing impairment in the mouse: A study of the acoustic startle reflex and its inhibition by brief decrements in noise level
Changes in temporal acuity with age and with hearing impairment in the mouse: A study of the acoustic startle reflex and its inhibition by brief decrements in noise level
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DOI：
10.1121/1.424382
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发表时间：
1998-09-01
影响因子：
2.4
通讯作者：
Vaughn, WJ
中科院分区：
文献类型：
--
作者：
Ison, JR;Agrawal, P;Vaughn, WJ
采用反射式改良测听技术，研究了不同年龄（1-36个月）小鼠对噪声短暂间隙的颞叶敏锐度，这些小鼠来自不同年龄相关性听力损失易感性的品系。脉冲前对声惊反射（ASR）的抑制作用随着间隙深度（GD: 10 ~ 40 dB， 70 dB声压级噪声）和间隔时间（LT: 1 ~ 15 ms）的增加而增强。LT对抑制的增加遵循一个指数函数，其中两个参数，渐近抑制（AINH）和时间常数（tau）都受到GD的影响。在进行性重度听力损失的C57BL/6J小鼠中，AINH在1 ~ 6月龄迅速下降，然后在18月龄迅速下降，但在CBA/CaJ和CBAXC57BL f1杂交小鼠中，AINH在6 ~ 12月龄后先升高，然后逐渐下降，这些年龄的感觉功能没有明显变化。相比之下，tau蛋白不受听力损失或年龄的影响，这表明这种颞叶敏锐度的年龄相关变化是因为集中处理间隙的效率降低，而不是因为跟随噪音水平快速变化的能力降低。(C) 1998美国声学学会。[s0001 - 4966 (98) 03608 - x)
Temporal acuity for brief gaps in noise was studied in mice of different ages (1-36 months) from strains with differing susceptibility to age-related hearing loss, using reflex modification audiometry. Prepulse inhibition of the acoustic startle reflex (ASR) increased with gap depth (GD: 10-40 dB in 70 dB SPL noise) and lead time (LT: 1-15 ms). The increase in inhibition with LT followed an exponential function in which the two parameters, asymptotic inhibition (AINH) and the time constant (tau), were both affected by GD. AINH rapidly declined from 1 to 6 and then to 18 months of age in C57BL/6J mice with progressively severe hearing loss, but first increased with maturation and then gradually declined beyond 6-12 months of age in CBA/CaJ and CBAXC57BL F1-hybrid mice, which show no apparent change in sensory function at these ages. In contrast, tau was unaffected by hearing loss or by age, this suggesting that age-related changes in this form of temporal acuity occur because of a reduction in the efficiency with which gaps are centrally processed, not from any reduced ability to follow their rapid shift in noise level. (C) 1998 Acoustical Society of America. [S0001-4966(98)03608-X]