Trace level determination of organophosphorus pesticides in water with the new direct-electron ionization LC/MS interface
Trace level determination of organophosphorus pesticides in water with the new direct-electron ionization LC/MS interface
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DOI：
10.1021/ac015685f
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发表时间：
2002-07-15
影响因子：
7.4
通讯作者：
Mangani, F
中科院分区：
文献类型：
--
作者：
Cappiello, A;Famiglini, G;Mangani, F
提出了一种基于直接电子电离(EI)界面的LC/MS测定水中有机磷农药的新方法。Direct-EI是一种新设备，它以一种非常简单的方式，将纳米高效液相色谱系统与配备有电子电离能力的质谱仪结合在一起。纳米级的液体流动允许将洗脱液直接引入离子源，并在雾化后在典型的EL条件下使其电离。为分析物的全扫描或SIM检测选择生成与库匹配的电致发光光谱。在我们的案例中，考虑了当地甜菜种植中常见的有机磷农药的选择。新的界面允许在很宽的线性响应范围(0.09-9 ng)内非常灵敏地检测分析物。当应用于实际样品时，该方法可以在大约3ng.L-1的浓度水平上检测四种不同的农药。
A new LC/MS method for the determination of organophosphorus pesticides in water, based on the use of direct-electron ionization (EI) interface, is presented. Direct-EI is a new device that, in a very simple fashion, couples a nano-HPLC system with a mass spectrometer equipped with electron ionization capability. The nanoscale liquid flow allows for a direct introduction of eluate into the ion source and, after nebulization, for its ionization under typical El conditions. Library-matchable El spectra are generated for a choice of full scan or SIM detection of the analytes. In our case, a selection of organophosphorus pesticides, commonly distributed in local sugar beet cultivation, were considered. The new interface permits a very sensitive detection of the analytes in a wide range of linear response (0.09-9 ng). When applied to a real sample, the method allowed detecting four different pesticides at a concentration level of approximately 3 ng.L-1.