Toxoplasma gondii infection blocks the development of allergic airway inflammation in BALB/c mice
Toxoplasma gondii infection blocks the development of allergic airway inflammation in BALB/c mice
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DOI：
10.1111/j.1365-2249.2008.03813.x
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发表时间：
2009-02-01
影响因子：
4.6
通讯作者：
Goldman, A.
中科院分区：
文献类型：
--
作者：
Fenoy, I.;Giovannoni, M.;Goldman, A.
在西方国家，过敏症的增加与某些感染的减少之间存在联系。流行病学数据还表明，呼吸道过敏在暴露于口粪和食源性微生物（如弓形虫）的人群中不太常见。感染猫弓首蛔虫弓形虫在感染的早期阶段诱导具有高度极化的辅助性T细胞1型（Th 1）应答的强细胞介导的免疫。使用一个众所周知的小鼠过敏性肺部炎症模型，我们试图研究T。弓形虫感染可调节发生呼吸道过敏的易感性。急性和慢性T.在过敏性致敏之前，弓形虫导致过敏性炎症减轻，如支气管肺泡灌洗（BAL）嗜酸性粒细胞增多、气道和血管周围单核细胞和嗜酸性粒细胞浸润以及杯状细胞增生减少所示。检测到低水平的变应原特异性免疫球蛋白（IG）E和IgG 1以及高水平的变应原特异性IgG 2a血清抗体。观察到淋巴结细胞产生的白细胞介素（IL）-4和IL-5减少，而未检测到抗原特异性干扰素-γ增加。在来自感染小鼠的BAL中发现更高水平的调节细胞因子IL-10。这些结果表明，急性和慢性寄生虫感染基本上阻断了成年BALB/c小鼠气道炎症的发展。我们的结果支持T.弓形虫感染有助于防止人类过敏。
There is a link between increased allergy and a reduction of some infections in western countries. Epidemiological data also show that respiratory allergy is less frequent in people exposed to orofaecal and foodborne microbes such as Toxoplasma gondii. Infection with T. gondii induces a strong cell-mediated immunity with a highly polarized T helper type 1 (Th1) response in early stages of infection. Using a well-known murine model of allergic lung inflammation, we sought to investigate whether T. gondii infection could modulate the susceptibility to develop respiratory allergies. Both acute and chronic infection with T. gondii before allergic sensitization resulted in a diminished allergic inflammation, as shown by a decrease in bronchoalveolar lavage (BAL) eosinophilia, mononuclear and eosinophil cell infiltration around airways and vessels and goblet cell hyperplasia. Low allergen-specific immunoglobulin (Ig)E and IgG1 and high levels of allergen-specific IgG2a serum antibodies were detected. A decreased interleukin (IL)-4 and IL-5 production by lymph node cells was observed, while no antigen-specific interferon-gamma increase was detected. Higher levels of the regulatory cytokine IL-10 were found in BAL from infected mice. These results show that both acute and chronic parasite infection substantially blocked development of airway inflammation in adult BALB/c mice. Our results support the hypothesis that T. gondii infection contributes to protection against allergy in humans.