Human prorenin: pathophysiology and clinical implications.
Human prorenin: pathophysiology and clinical implications.
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人肾素原：病理生理学和临床意义。
DOI：
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Schalekamp Ma
中科院分区：
文献类型：
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作者：
Derkx Fh;Schalekamp Ma
摘要 肾素和肾素原，后者转化为肾素后，通常使用抗血管紧张素 I 的抗体通过间接 RIA 进行测量。现在也可以使用与总免疫反应性肾素（肾素加肾素原）或单独的肾素反应的单克隆抗体通过直接 RIA 来测量它们。肾和外周静脉血浆的测量结果表明，通常血浆中大部分肾素原是肾脏来源的，并且它们支持JG细胞分泌肾素和肾素的不同途径的概念。急性刺激导致血浆肾素迅速增加，而肾素原没有任何变化。在慢性刺激过程中，肾素和肾素原都会增加，刺激越强，两者之间的比例就越高。因此，在急性刺激下，只有储存的肾素的释放似乎会增加（调节途径），而在慢性刺激期间，肾素原的合成和分泌也会增加（组成性途径）。在怀孕期间，在...
ABSTRACTRenin and prorenin, the latter after conversion to renin, are usually measured by indirect RIA using antibodies against angiotensin I. They can now also be measured by direct RIA using monoclonal antibodies reacting with total immunoreactive renin (renin plus prorenin) or with renin alone. Results of measurements in renal and peripheral venous plasma indicate that normally a large proportion of prorenin in plasma is of renal origin and they support the concept of separate pathways for prorenin and renin secretion by the JG-cells. Acute stimulation causes a prompt increase of plasma renin without any change in prorenin. During chronic stimulation both renin and prorenin are increased, in such a way that the ratio between the two is higher the stronger the stimulus. Thus, with acute stimulation only the release of stored renin appears to be increased (regulated pathway), whereas during chronic stimulation the synthesis and secretion of prorenin are also (constitutive pathway).During pregnancy, in th...
影响因子：
158.5
作者：
LUETSCHER, JA;KRAEMER, FB;BRYERASH, M
通讯作者：
BRYERASH, M
血管紧张素 II 产生的新血管形成。
DOI：
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发表时间：
1985
期刊：
The Journal of laboratory and clinical medicine
影响因子：
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作者：
Fernandez,LA;Twickler,J;Mead,A
通讯作者：
Mead,A