The role of WNT signaling in adult ovarian folliculogenesis.
The role of WNT signaling in adult ovarian folliculogenesis.
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DOI：
10.1530/rep-14-0685
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发表时间：
2015-10
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影响因子：
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通讯作者：
Hernandez Gifford JA
中科院分区：
文献类型：
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作者：
Hernandez Gifford JA
无翼型小鼠乳腺肿瘤病毒整合位点（WNT）信号分子是局部分泌的糖蛋白，在许多生理和病理发育过程中发挥作用。 WNT 信号通路的组成部分已被证明会影响生殖功能，包括性器官的胚胎发育，以及控制产后卵巢中类固醇生成的卵泡成熟的调节。新的证据强调了 WNT 信号分子在调节生殖周期期间卵巢发生的动态变化方面的复杂性。虽然 WNT 信号级联的破坏已被认为会对正常性发育产生有害后果，但最近的研究开始强调这些分子在与卵泡发育、黄体形成、类固醇产生和生育能力相关的成人卵巢功能中的重要性。 WNT 基因的激素调节和 WNT 信号网络成员的表达，包括 WNT 配体、卷曲受体和下游信号元件，它们在发情周期的不同阶段在出生后卵巢中表达，表明在正常卵巢功能中发挥着至关重要的作用。同样，FSH 刺激 T 细胞因子依赖性基因表达需要 β-连环蛋白（经典 WNT 信号传导中的关键分子）的输入，进一步表明 β-连环蛋白参与卵泡成熟的调节。本综述将重点关注 WNT 信号在成人卵巢卵泡发生中的多种功能。
Wingless-type mouse mammary tumor virus integration site (WNT) signaling molecules are locally secreted glycoproteins that play a role in a number of physiological and pathological developmental processes. Components of the WNT signaling pathway have been demonstrated to impact reproductive functions including embryonic development of the sex organs, and regulation of follicle maturation controlling steroidogenesis in the postnatal ovary. Emerging evidence underscores the complexity of WNT signaling molecules in regulation of dynamic changes that occur in the ovary during the reproductive cycle. While disruption in the WNT signaling cascade has been recognized to have deleterious consequences to normal sexual development, more recent studies are beginning to highlight the importance of these molecules in adult ovarian function related to follicle development, corpus luteum formation, steroid production and fertility. Hormonal regulation of WNT genes and expression of members of the WNT signaling network, including WNT ligands, frizzled receptors and downstream signaling components that are expressed in the postnatal ovary at distinct stages of the estrous cycle, suggest a crucial role in normal ovarian function. Similarly, FSH stimulation of T cell factor-dependent gene expression requires input from β-catenin, a lynchpin molecule in canonical WNT signaling, further indicating β-catenin participation in regulation of follicle maturation. This review will focus on the multiple functions of WNT signaling in folliculogenesis in the adult ovary.