Hand-assisted retroperitoneoscopic versus standard laparoscopic donor nephrectomy: HARP-trial.
Hand-assisted retroperitoneoscopic versus standard laparoscopic donor nephrectomy: HARP-trial.
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DOI：
10.1186/1471-2482-10-11
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发表时间：
2010-03-25
期刊：
影响因子：
1.9
通讯作者：
Ijzermans JN
中科院分区：
文献类型：
--
作者：
Dols LF;Kok NF;Terkivatan T;Tran TC;d'Ancona FC;Langenhuijsen JF;zur Borg IR;Alwayn IP;Hendriks MP;Dooper IM;Weimar W;Ijzermans JN
移植是唯一能为慢性肾衰竭患者提供长期益处的治疗方法。活体供肾切除术是在健康个体身上进行的，他们本身并没有从手术中获得直接的治疗益处。为了保证供体的安全，重要的是优化手术入路。最近我们证实了供肾者腹腔镜肾切除术的益处。然而，这种方法的特点是医院成本较高，手术时间较长，并且需要训练有素的外科医生。手辅助后腹腔镜技术可能是一种替代完整的腹腔镜，经腹膜途径。腹膜保持完整，内脏损伤的风险降低。手动辅助可加快手术速度并显著缩短手术时间。这种方法的可行性最近已得到证明，但迄今为止，还没有任何数据支持使用一种技术。HARP试验是一项多中心随机对照、单盲试验。该研究比较了手辅助后腹腔镜方法与标准腹腔镜供肾切除术。目的是确定活体供肾切除术的最佳方法，以优化供肾者的安全性和舒适性，同时降低供肾相关费用。这项研究将有助于证明手辅助后腹腔镜与标准腹腔镜供体肾切除术的任何好处。荷兰试验登记册NTR 1433
Transplantation is the only treatment offering long-term benefit to patients with chronic kidney failure. Live donor nephrectomy is performed on healthy individuals who do not receive direct therapeutic benefit of the procedure themselves. In order to guarantee the donor's safety, it is important to optimise the surgical approach. Recently we demonstrated the benefit of laparoscopic nephrectomy experienced by the donor. However, this method is characterised by higher in hospital costs, longer operating times and it requires a well-trained surgeon. The hand-assisted retroperitoneoscopic technique may be an alternative to a complete laparoscopic, transperitoneal approach. The peritoneum remains intact and the risk of visceral injuries is reduced. Hand-assistance results in a faster procedure and a significantly reduced operating time. The feasibility of this method has been demonstrated recently, but as to date there are no data available advocating the use of one technique above the other. The HARP-trial is a multi-centre randomised controlled, single-blind trial. The study compares the hand-assisted retroperitoneoscopic approach with standard laparoscopic donor nephrectomy. The objective is to determine the best approach for live donor nephrectomy to optimise donor's safety and comfort while reducing donation related costs. This study will contribute to the evidence on any benefits of hand-assisted retroperitoneoscopic versus standard laparoscopic donor nephrectomy. Dutch Trial Register NTR1433
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影响因子：
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