Hippocampal, Amygdala, and Neocortical Synchronization of Theta Rhythms is Related to an Immediate Recall During Rey Auditory Verbal Learning Test
Hippocampal, Amygdala, and Neocortical Synchronization of Theta Rhythms is Related to an Immediate Recall During Rey Auditory Verbal Learning Test
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DOI：
10.1002/hbm.20648
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发表时间：
2009-07-01
影响因子：
4.8
通讯作者：
Eusebi, Fabrizio
中科院分区：
文献类型：
--
作者：
Babiloni, Claudio;Vecchio, Fabrizio;Eusebi, Fabrizio
众所周知，theta 节律（3-8 Hz）是海马体的指纹，并且伴随单词编码的神经活动根据随后记住或忘记的项目而不同[“后续记忆效应”（SME）]。在这里，我们测试了这样的假设：海马体、杏仁核和新皮质之间的 θ 节律的时间同步与重复单词的即时记忆有关。为了解决这个问题，在术前常规监测下，记录了 5 名耐药颞叶癫痫 (TLE) 受试者的脑内脑电图 (EEG) 活动。在记录脑内脑电图活动期间，受试者进行了计算机化版本的雷伊听觉语言学习测试（RAVLT），这是一种用于临床评估即时和延迟记忆的流行测试。他们听了同一个 15 个常用单词五次。每次，在听完列表后，受试者都被要求重复尽可能多的他们能回忆起的单词。计算脑内脑电图活动的频谱相干性，以评估海马、杏仁核和颞枕新皮质之间的 theta（约 3-8 Hz）节律的时间同步性。我们发现，成功立即回忆过程中，杏仁核和海马体之间以及海马体和枕颞皮层之间的 θ 一致性值的幅度高于不成功的立即回忆过程。对照分析表明，对于伽玛波段（40-45 Hz）也是如此。此外，在另一名患有耐药性 TLE 且海马体广泛病变的受试者（对照）中没有观察到这些 θ 和 γ 效应。总之，成功立即回忆 RAVLT 与大脑网络（包括海马体、杏仁核和颞枕新皮质）内 θ（γ）节律的时间同步性增强有关。 Hum Brain Mapp 30:2077-2089, 2009。(C) 2008 Wiley-Liss, Inc.
It is well known that theta rhythms (3-8 Hz) are the fingerprint of hippocampus, and that neural activity accompanying encoding of words differs according to whether the items are later remembered or forgotten ["subsequent memory effect" (SME)]. Here, we tested the hypothesis that temporal synchronization of theta rhythms among hippocampus, amygdala, and neocortex is related to immediate memorization of repeated words. To address this issue, intracerebral electroencephalographic (EEG) activity was recorded in five subjects with drug-resistant temporal lobe epilepsy (TLE), under presurgical monitoring routine. During the recording of the intracerebral EEG activity, the subjects performed a computerized version of Rey auditory verbal learning test (RAVLT), a popular test for the clinical evaluation of the immediate and delayed memory. They heard the same list of 15 common words for five times. Each time, immediately after listening the list, the subjects were required to repeat as many words as they could recall. Spectral coherence of the intracerebral EEG activity was computed in order to assess the temporal synchronization of the theta (about 3-8 Hz) rhythms among hippocampus, amygdala, and temporal-occipital neocortex. We found that theta coherence values between amygdala and hippocampus, and between hippocampus and occipital-temporal cortex, were higher in amplitude during successful than unsuccessful immediate recall. A control analysis showed that this was true also for a gamma band (40-45 Hz). Furthermore, these theta and gamma effects were not observed in an additional (control) subject with drug-resistant TLE and a wide lesion to hippocampus. In conclusion, a successful immediate recall to the RAVLT was associated to the enhancement of temporal synchronization of the theta (gamma) rhythms within a cerebral network including hippocampus, amygdala, and temporal-occipital neocortex. Hum Brain Mapp 30:2077-2089, 2009. (C) 2008 Wiley-Liss, Inc.