Visualization of human prenatal development by magnetic resonance Imaging (MRI)
Visualization of human prenatal development by magnetic resonance Imaging (MRI)
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DOI：
10.1002/ajmg.a.31994
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发表时间：
2007-12-15
影响因子：
2
通讯作者：
Matsuda, Tetsuya
中科院分区：
文献类型：
--
作者：
Shiota, Kohei;Yamada, Shigehito;Matsuda, Tetsuya
胚胎及其内部器官的三维可视化结构对分析形态发生至关重要;这过去仅依赖于连续组织切片和实体重建，这是繁琐和耗时的。我们使用配备2.35 T超导磁体的磁共振（MR）显微镜进行成像，以可视化人类胚胎;我们成功地获取了高分辨率的断层图像并识别了主要器官的详细结构。通过使用超平行MR显微镜来促进成像过程。现在收集的1,000多个人类胚胎的MR图像数据集对于未来的生物医学研究和教育将非常重要。(C)2007 Wiley-Liss，Inc.
It is essential to visualize the structures of embryos and their internal organs three-dimensionally to analyze morphogenesis; this used to rely solely on serial histological sectioning and solid reconstruction, which were tedious and time-consuming. We have applied imaging with a magnetic resonance (MR) microscope equipped with a 2.35 T superconducting magnet to visualize human embryos; we were Successful in acquiring high-resolution sectional images and in identifying the detailed structures of major organs. The imaging process was facilitated by using a super-parallel MR microscope. A dataset of MR images of more than 1,000 human embryos, now collected, will be important for future biomedical research and for education. (C) 2007 Wiley-Liss, Inc.