Nanomedicine-mediated regulated cell death in cancer immunotherapy.
Nanomedicine-mediated regulated cell death in cancer immunotherapy.
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DOI：
10.1016/j.jconrel.2023.10.032
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发表时间：
2023-10
期刊：
影响因子：
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通讯作者：
Yue Sun;Ting Lian;Qichao Huang;Yawei Chang;Yuan Li;Xiaoyu Guo;Weirong Kong;Yifang Yang
中科院分区：
文献类型：
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作者：
Yue Sun;Ting Lian;Qichao Huang;Yawei Chang;Yuan Li;Xiaoyu Guo;Weirong Kong;Yifang Yang
免疫治疗在肿瘤治疗中引起了广泛的关注，并在部分肿瘤的临床治疗中取得了相当大的成功，但在大多数肿瘤中反应率较低。为了实现免疫应答的充分激活，已经做出了使用纳米技术来增强癌症免疫应答的显著努力。近年来，诱导各种调节性细胞死亡（RCD）已成为一种潜在的抗肿瘤免疫策略，包括与凋亡、自噬、坏死性凋亡、焦亡、铁亡和铜亡相关的过程。特别地，从死亡细胞的受损膜释放的损伤相关分子模式（DAMP）充当原位佐剂以通过暴露增加的抗原性来触发抗原特异性免疫应答。因此，基于RCD的免疫疗法为增强癌症治疗效果提供了一种新方法。此外，在基于细胞死亡的免疫疗法中结合多模式辅助疗法可以引发更强的免疫应答，从而产生更有效的治疗结果。这篇综述讨论了不同的RCD模式，并总结了最近的纳米技术介导的RCD在癌症免疫治疗。
Immunotherapy has attracted widespread attention in cancer treatment and has achieved considerable success in the clinical treatment of some tumors, but it has a low response rate in most tumors. To achieve sufficient activation of the immune response, significant efforts using nanotechnology have been made to enhance cancer immune response. In recent years, the induction of various regulated cell death (RCD) has emerged as a potential antitumor immuno-strategy, including processes related to apoptosis, autophagy, necroptosis, pyroptosis, ferroptosis, and cuproptosis. In particular, damage-associated molecular patterns (DAMPs) released from the damaged membrane of dying cells act asin situadjuvants to trigger antigen-specific immune responses by the exposure of an increased antigenicity. Thus, RCD-based immunotherapy offers a new approach for enhancing cancer treatment efficacy. Furthermore, incorporation with multimodal auxiliary therapies in cell death-based immunotherapy can trigger stronger immune responses, resulting in more efficient therapeutic outcome. This review discusses different RCD modalities and summarizes recent nanotechnology-mediated RCDs in cancer immunotherapy.