Association between air pollution and lung function growth in southern California children.
Association between air pollution and lung function growth in southern California children.
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DOI：
10.1164/ajrccm.162.4.9909096
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发表时间：
2000-10
影响因子：
24.7
通讯作者：
W. Gauderman;Rob M C Connell;F. Gilliland;Stephanie A. London;Duncan C. Thomas;E. Avol;Hita Vora;K. Berhane;E. Rappaport;F. Lurmann;H. Margolis;J. Peters;J. Gauderman
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文献类型：
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作者：
W. Gauderman;Rob M C Connell;F. Gilliland;Stephanie A. London;Duncan C. Thomas;E. Avol;Hita Vora;K. Berhane;E. Rappaport;F. Lurmann;H. Margolis;J. Peters;J. Gauderman
1993年，在三个队列的南加州四年级、七年级或十年级儿童中，4年期间肺功能的平均增长被建模为平均暴露于环境空气污染物的函数。在四级队列中，肺功能（FEV（1）、FVC、最大呼气中段流量[MMEF]和FEF（75））的显著增长缺陷与空气动力学直径小于10微米的颗粒（PM（10））、PM（2.5）、PM（10）-PM（2.5）、NO（2）和无机酸蒸气的暴露相关（p < 0.05）。未观察到与臭氧的显著关联。与污染最轻的社区相比，污染最严重的社区儿童的估计增长率预计将导致在4年研究期间FEV（1）和MMEF累计减少3.4%和5.0%。估计赤字一般较大的儿童花更多的时间在户外。在七年级和十年级的队列中，估计的污染物影响对大多数肺功能指标也是负面的，但这些组的样本量较低，没有达到统计学意义。结果表明，在目前的颗粒物、NO（2）和无机酸蒸气的环境浓度下，对儿童肺功能发育有显著的负面影响。
Average growth of lung function over a 4-yr period, in three cohorts of southern California children who were in the fourth, seventh, or tenth grade in 1993, was modeled as a function of average exposure to ambient air pollutants. In the fourth-grade cohort, significant deficits in growth of lung function (FEV(1), FVC, maximal midexpiratory flow [MMEF], and FEF(75)) were associated with exposure to particles with aerodynamic diameter less than 10 micrometer (PM(10)), PM(2.5), PM(10)-PM(2.5), NO(2), and inorganic acid vapor (p < 0.05). No significant associations were observed with ozone. The estimated growth rate for children in the most polluted of the communities as compared with the least polluted was predicted to result in a cumulative reduction of 3.4% in FEV(1) and 5.0% in MMEF over the 4-yr study period. The estimated deficits were generally larger for children spending more time outdoors. In the seventh- and tenth-grade cohorts, the estimated pollutant effects were also negative for most lung function measures, but sample sizes were lower in these groups and none achieved statistical significance. The results suggest that significant negative effects on lung function growth in children occur at current ambient concentrations of particles, NO(2), and inorganic acid vapor.