Study of association between sickle cell trait and renal dysfunction among young adults in South-west Nigeria
Study of association between sickle cell trait and renal dysfunction among young adults in South-west Nigeria
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DOI：
10.4103/njcp.njcp_253_18
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发表时间：
2019-02-01
影响因子：
0.9
通讯作者：
Falekulo, O. K.
中科院分区：
文献类型：
--
作者：
Akinbodewa, A. A.;Ogunleye, A.;Falekulo, O. K.
背景：尽管镰状细胞病已成为慢性肾病 (CKD) 的公认病因，但直到最近，镰状细胞性状 (SCT) 变异体还被认为是一种良性携带状态，对受影响个体的健康影响很小或没有影响。然而，最近的研究似乎表明 SCT 和 CKD 之间存在关联。目的：本研究的目的是确定 SCT（血红蛋白 AS）与尼日利亚年轻人肾功能障碍之间的关联。方法：这是一项横断面、描述性研究，对象是尼日利亚西南部翁多市阿德耶米教育学院表面健康的本科生。使用标准碱性电泳确定他们的血红蛋白基因型；测定了他们的血压、人体测量学、血清总胆固醇（TC）、肌酐和估计肾小球滤过率（eGFR）。使用社会科学统计软件包 (SPSS) 20 分析的数据显着，P < 0.05。结果：对 602 名患有 HbAS（SCT，n = 465）和 HbAA（非 SCT，n = 137）的受试者进行了研究。年龄范围18岁至30岁，男女比例1：3.8。 SCT 和非 SCT 受试者之间肾功能不全的患病率没有差异（5.1% vs. 5.2%，P = 0.591）。 SCT 受试者的 CKD 风险并未增加（PR，95% CI 为 0.99 [0.417u2.348]）。结论：SCT 与尼日利亚年轻人肾功能障碍风险增加无关。需要进一步的研究来澄清这一争议，特别是在 SCT 患病率相对较高的尼日利亚。
Background: Although sickle cell disease has become a recognized etiology of chronic kidney disease (CKD), the sickle cell trait (SCT) variant was until recently believed to be a benign carrier state with little or no effect on the health of affected individuals. However, recent studies now appear to suggest an association between SCT and CKD. Objective: The objective of the study is to determine the association between SCT (hemoglobin AS) and renal dysfunction among young Nigerian adults. Methodology: This was a cross-sectional, descriptive study among apparently healthy undergraduates of Adeyemi College of Education, Ondo, southwest Nigeria. Their hemoglobin genotypes were determined using standard alkaline electrophoresis; their blood pressure, anthropometry, serum total cholesterol (TC), creatinine, and estimated glomerular filtration rate (eGFR) were determined. Data analyzed using Statistical Package for Social Sciences (SPSS) 20 were significant at P < 0.05. Results: Six hundred and two subjects with HbAS (SCT, n = 465) and HbAA (non-SCT, n = 137) were studied. Their age range was 18u30 years with male-to-female ratio 1:3.8. There was no difference in the prevalence of renal dysfunction between SCT and non-SCT subjects (5.1% vs. 5.2%, P = 0.591). There was no increased risk of CKD among subjects with SCT (PR, 0.99 at 95% CI [0.417u2.348]). Conclusion: SCT was not associated with increased risk of renal dysfunction among young adults in Nigeria. Further studies are needed to clarify the controversy, especially in Nigeria, with a relatively higher prevalence of SCT.