Relative roles of inhibin B and sex steroids in the negative feedback regulation of follicle-stimulating hormone in men across the full spectrum of seminiferous epithelium function
Relative roles of inhibin B and sex steroids in the negative feedback regulation of follicle-stimulating hormone in men across the full spectrum of seminiferous epithelium function
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DOI：
10.1210/jc.2007-2450
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发表时间：
2008-05-01
影响因子：
5.8
通讯作者：
Pitteloud, Nelly
中科院分区：
文献类型：
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作者：
Boepple, Paul A.;Hayes, Frances J.;Pitteloud, Nelly
背景和目的：我们的目的是探讨性激素和抑制素B在精子上皮功能谱中调控卵泡刺激素的相对作用。研究对象：研究分为三组：第一组，健康男性（n = 31）；II组，接受脉动性GnRH治疗的特发性促性腺功能减退症男性（n = 12），选择代表精管发育谱、睾丸大小和基线抑制素B水平；第三组，功能性性功能障碍患者（n = 3）接受睾酮替代治疗。设计：受试者在急性性类固醇停药前和停药后进行研究。环境：本研究在马萨诸塞州总医院Mallinckrodt综合临床研究中心进行。干预措施：采用大剂量酮康唑（I组和II组）或停止雄激素治疗（III组）实现急性生化去势。主要观察指标：测定正常和去势性类固醇环境中FSH与抑制素B的关系。结果：在正常和去势性类固醇环境中，抑制素B与FSH呈负相关，最好用对数模型来描述。在基线抑制素B水平最低的男性中，急性生化去势导致FSH最显著的增加。结论：我们得出以下结论：1)在人类男性中，抑制素B是FSH分泌的主要性腺反馈调节剂，除非精管功能严重受损，并且对数模型最好地描述了这种关系；2)当血清抑制素B水平远低于正常范围时，性类固醇对FSH分泌的抑制最为明显。
Context and Objective: Our aim was to explore the relative roles of gonadal sex steroids and inhibin B in the regulation of FSH across a spectrum of seminiferous epithelium function.Subjects: The study included three groups: group I, healthy men (n = 31); group II, men with idiopathic hypogonadotropic hypogonadism receiving pulsatile GnRH (n = 12) selected to represent a spectrum of seminiferous tubular development, testicular size, and baseline inhibin B levels; and group III, men with functional anorchia (n = 3) receiving testosterone replacement.Design: Subjects were studied before and after 3 d of acute sex steroid withdrawal.Setting: The study was conducted at the Mallinckrodt General Clinical Research Center of Massachusetts General Hospital.Interventions: Acute biochemical castration was achieved using high-dose ketoconazole (groups I and II) or withdrawal of androgen therapy (group III).Main Outcome Measures: The relationship between FSH and inhibin B in both normal and castrate sex steroid milieu was measured.Results: In both normal and castrate sex steroid milieus, there was a negative relationship between inhibin B and FSH, best described by a logarithmic model. Acute biochemical castration resulted in the most dramatic increases in FSH in men with the lowest baseline inhibin B levels.Conclusions: We came to the following conclusions: 1) in the human male, inhibin B is the principal gonadal feedback regulator of FSH secretion unless seminiferous tubular function is severely compromised, and a logarithmic model best describes this relationship; and 2) sex steroid inhibition of FSH secretion is most apparent when serum inhibin B levels fall well below the normal range.