Peritrophic matrix proteins of Anopheles gambiae and Aedes aegypti
Peritrophic matrix proteins of Anopheles gambiae and Aedes aegypti
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DOI：
10.1111/j.1365-2583.1996.tb00100.x
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发表时间：
1996-11-01
影响因子：
2.6
通讯作者：
JacobsLorena, M
中科院分区：
文献类型：
--
作者：
Moskalyk, LA;Oo, MM;JacobsLorena, M
蚊子围食基质（PM）的组成和功能知之甚少，PM是病原体必须穿过以完成其生命周期的物理屏障。冈比亚按蚊（Anopheles gambiae）和埃及伊蚊（Aedes aegypti）的PM蛋白质由血液或无蛋白质食物诱导，其特征在于使用2-D凝胶电泳和凝集素结合亲和力测定。两种蚊子的PM蛋白的一半以上相同地迁移。许多PM蛋白似乎是糖基化的，主要是由高甘露糖N-连接的糖基基团。
Little is known about the composition and function of the mosquito peritrophic matrix (PM), a physical barrier that pathogens must traverse to complete their life cycles. Anopheles gambiae and Aedes aegypti PM proteins induced by blood or by a protein-free meal have been characterized by the use of 2-D gel electrophoresis and lectin-binding affinity assays, More than forty proteins have been identified in both species. Over half of the PM proteins of both mosquitoes migrate identically, Many PM proteins appear to be glycosylated, primarily by high mannose N-linked glycosyl groups.