Effect of Model Thrombus Volume and Elastic Modulus on Magnetomotive Ultrasound Signal Under Pulsatile Flow.
Effect of Model Thrombus Volume and Elastic Modulus on Magnetomotive Ultrasound Signal Under Pulsatile Flow.
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DOI：
10.1109/tuffc.2018.2841774
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发表时间：
2018-08
期刊：
影响因子：
--
通讯作者：
Oldenburg AL
中科院分区：
文献类型：
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作者：
Levy BE;Hossain MM;Sierchio JM;Thapa D;Gallippi CM;Oldenburg AL
动脉和静脉血栓的直接超声成像可以通过提供血栓体积和弹性模量的快速且具有成本效益的测量来帮助诊断和治疗计划。为此，已证明，露天磁动超声（MMUS）提供了特定的对比超顺磁性氧化铁（SPIO）标记的模型血栓嵌入明胶血管模拟流动幻影。在存在模拟在真实的脉管系统中发现的心脏诱导运动的脉动流的情况下对模型血栓进行MMUS。在生理相关血栓体积和弹性模量范围内测量MMUS信号和对比噪声比（CNR）。小至0.5ml的模型血栓体积在测试的整个弹性模量范围（3.5 - 40 kPa）内显示为可检测的（CNR > 1）。还发现MMUS信号和CNR随着血栓体积的增加（r = 0.99）和弹性模量的降低（r =-0.81）而增加，而脉动流速的变化几乎没有影响。这些发现表明，MMUS有希望作为一种直接的体内血栓形成成像模式，用于量化血栓体积和硬度。
Direct ultrasonic imaging of arterial and venous thrombi could aid in diagnosis and treatment planning by providing rapid and cost-effective measurements of thrombus volume and elastic modulus. Toward this end, it was demonstrated that open-air magnetomotive ultrasound (MMUS) provides specific contrast to superparamagnetic iron oxide (SPIO)-labelled model thrombi embedded in gelatin-based blood vessel-mimicking flow phantoms. MMUS was performed on model thrombi in the presence of pulsatile flow that mimics cardiac-induced motion found in real vasculature. The MMUS signal and contrast to noise ratio (CNR) was measured across a range of physiologically relevant thrombus volumes and elastic moduli. Model thrombus volumes as small as 0.5 ml were shown to be detectable (CNR > 1) over the entire range of elastic moduli tested (3.5 – 40 kPa). It was also found that MMUS signal and CNR increased with increasing thrombus volume (r = 0.99), and decreasing elastic modulus (r = −0.81), while variations in pulsatile flow rate had little effect. These findings demonstrate that MMUS has promise as a direct in vivo thrombosis imaging modality for quantifying thrombus volume and stiffness.