MOISTURE-ACTIVATED, ELECTRICALLY CONDUCTING BIOADHESIVE HYDROGELS AS INTERFACES FOR BIOELECTRODES - EFFECT OF FILM HYDRATION ON CUTANEOUS ADHERENCE IN WET ENVIRONMENTS
MOISTURE-ACTIVATED, ELECTRICALLY CONDUCTING BIOADHESIVE HYDROGELS AS INTERFACES FOR BIOELECTRODES - EFFECT OF FILM HYDRATION ON CUTANEOUS ADHERENCE IN WET ENVIRONMENTS
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DOI：
10.1002/app.1995.070580810
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发表时间：
1995-11-21
影响因子：
3
通讯作者：
ANDERSON, JM
中科院分区：
文献类型：
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作者：
WOOLFSON, AD;MCCAFFERTY, DF;ANDERSON, JM
用连续重量法测定了聚（甲基乙烯基醚-马来酸酐）共聚物生物粘附膜在两种湿度和两种温度下的含水量。薄膜的含水量在增加湿度的储存条件下增加。这些膜的生物粘附性使用先前在我们实验室验证的体外生物粘附性测试仪进行评估。考虑生物粘附测试期间的水吸收，并将膜的最终水含量记录为“校正的平衡水含量”（CEWC）。使用标准曲线拟合分析开发了在23和35摄氏度下储存的膜的生物粘附性和CEWC之间的良好质量的二阶多项式关系。A 2 X 2析因设计实验表明，温度和相对湿度百分比之间存在协同关系，它们对聚合物膜的生物粘附性的影响，可能是由于它们对膜含水量的联合作用。这些发现对亲水性聚合物膜的储存和包装都有影响。(C)John Wiley & Sons，Inc.
The water contents of bioadhesive polymeric films of poly(methylvinyl ether-maleic anhydride) copolymer, stored at two humidities and at two temperatures, have been determined by continuous gravimetry. The water contents of the films increased under storage conditions of increasing humidity. The bioadhesion of these films was assessed using an in vitro bioadhesive tester previously validated in our laboratory. Water uptake during the bioadhesive test was taken into account and the final water content of films recorded as a ''corrected equilibrium water content'' (CEWC). A good quality second-order polynomial relationship between bioadhesion and the CEWC of films stored at both 23 and 35 degrees C was developed using standard curve fitting analyses. A 2 X 2 factorial design experiment revealed that there was a synergistic relationship between temperature and percentage relative humidity with regard to their effect on the bioadhesion of polymeric films, presumably due to their combined effect on film water content. These findings have implications for both the storage and packaging of hydrophilic polymeric films. (C) 1995 John Wiley & Sons, Inc.