TREM2 Mediates Microglial Anti-Inflammatory Activations in Alzheimer's Disease: Lessons Learned from Transcriptomics.
TREM2 Mediates Microglial Anti-Inflammatory Activations in Alzheimer's Disease: Lessons Learned from Transcriptomics.
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TREM2介导阿尔茨海默病的小胶质细胞抗炎激活：转录组学的经验教训
作者：
Xue F;Du H
阿尔茨海默病（Alzheimer's disease，AD）是一种主要影响老年人的致命性神经退行性疾病。AD的发病机制，尤其是散发型AD的发病机制至今仍不清楚。髓样细胞触发受体2（triggeringreceptor expressedonmyeloidcells 2，TREM2）是TREM免疫球蛋白超家族的成员，在小胶质细胞生理学中起着重要作用。人类TREM2中的错义突变被确定为与散发性AD发展相关的遗传风险因素。然而，TREM2在AD发病机制中的作用仍有待确定。在这篇综述中，我们概述了Trem2的促炎和抗炎小胶质细胞激活的平衡的影响，从AD小鼠模型转录组学的角度。在此基础上，我们进一步推测了TREM2在AD不同阶段的作用，这可能为开发以TREM2为靶点的防治AD的策略提供参考。
Alzheimer’s disease (AD) is a lethal neurodegenerative disorder primarily affecting the aged population. The etiopathogenesis of AD, especially that of the sporadic type, remains elusive. The triggering receptor expressed on myeloid cells 2 (TREM2), a member of TREM immunoglobulin superfamily, plays a critical role in microglial physiology. Missense mutations in human TREM2 are determined as genetic risk factors associated with the development of sporadic AD. However, the roles of TREM2 in the pathogenesis of AD are still to be established. In this review, we outlined the influence of Trem2 on balance of pro- and anti-inflammatory microglial activations from a perspective of AD mouse model transcriptomics. On this basis, we further speculated the roles of TREM2 in different stages of AD, which may shed light to the development of TREM2-targeted strategy for the prevention and treatment of this neurodegenerative disorder.
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DOI：
10.1056/nejmoa1211851
发表时间：
2013-01-10
期刊：
The New England journal of medicine
影响因子：
--
作者：
Guerreiro R;Wojtas A;Bras J;Carrasquillo M;Rogaeva E;Majounie E;Cruchaga C;Sassi C;Kauwe JS;Younkin S;Hazrati L;Collinge J;Pocock J;Lashley T;Williams J;Lambert JC;Amouyel P;Goate A;Rademakers R;Morgan K;Powell J;St George-Hyslop P;Singleton A;Hardy J;Alzheimer Genetic Analysis Group
通讯作者：
Alzheimer Genetic Analysis Group
TREM2上调与阿尔茨海默氏病海马的5-羟基环胞嘧啶富集相关。
影响因子：
5.7
作者：
Celarain N;Sánchez-Ruiz de Gordoa J;Zelaya MV;Roldán M;Larumbe R;Pulido L;Echavarri C;Mendioroz M
通讯作者：
Mendioroz M
影响因子：
25
作者：
Grubman, Alexandra;Chew, Gabriel;Polo, Jose M.
通讯作者：
Polo, Jose M.
影响因子：
5.8
作者：
Jiang J;Wang C;Qi R;Fu H;Ma Q
通讯作者：
Ma Q
影响因子：
7.3
作者：
Errichiello, Edoardo;Dardiotis, Efthimios;Zuffardi, Orsetta
通讯作者：
Zuffardi, Orsetta