A temporal predictive code for voice motor control: Evidence from ERP and behavioral responses to pitch-shifted auditory feedback.
A temporal predictive code for voice motor control: Evidence from ERP and behavioral responses to pitch-shifted auditory feedback.
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DOI：
10.1016/j.brainres.2016.01.040
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发表时间：
2016-04-01
期刊：
影响因子：
2.9
通讯作者：
Larson CR
中科院分区：
文献类型：
--
作者：
Behroozmand R;Sangtian S;Korzyukov O;Larson CR
预测编码模型表明，语音运动控制是由一个过程，其中前馈预测和感觉反馈之间的不匹配（错误）被检测到，并用于纠正声乐运动行为。在这项研究中，我们调查了语音听觉反馈中音高扰动的时间预测如何调节发声过程中的ERP和行为反应。我们设计了六个平衡块，其中+100美分音高移位刺激扰动元音发声过程中的语音听觉反馈。在三个区块中，语音和音高变化刺激开始（可预测）之间存在固定延迟（500，750或1000 ms），而在其他三个区块中，刺激开始延迟在500，750和1000 ms之间随机分配（不可预测）。我们发现，受试者产生的补偿（反对）的声音反应，开始在80毫秒后的不可预测的刺激。然而，对于可预测的刺激，受试者在20 ms前启动声音反应，并遵循语音反馈中的音高变化方向。事件相关电位的分析表明，与不可预测的刺激相比，N1和P2成分的振幅显着降低。这些发现表明，对感觉反馈的时间特征的预测可以调节发声运动行为。在预测编码模型的上下文中，时间可预测的刺激被内部前馈系统学习和加强，并且如由ERP抑制所索引的，感觉反馈贡献对于它们的处理被减少。这些发现提供了新的见解发声和运动控制的神经机制。
The predictive coding model suggests that voice motor control is regulated by a process in which the mismatch (error) between feedforward predictions and sensory feedback is detected and used to correct vocal motor behavior. In this study, we investigated how predictions about timing of pitch perturbations in voice auditory feedback would modulate ERP and behavioral responses during vocal production. We designed six counterbalanced blocks in which a +100 cents pitch-shift stimulus perturbed voice auditory feedback during vowel sound vocalizations. In three blocks, there was a fixed delay (500, 750 or 1000 ms) between voice and pitch-shift stimulus onset (predictable), whereas in the other three blocks, stimulus onset delay was randomized between 500, 750 and 1000 ms (unpredictable). We found that subjects produced compensatory (opposing) vocal responses that started at 80 ms after the onset of the unpredictable stimuli. However, for predictable stimuli, subjects initiated vocal responses at 20 ms before and followed the direction of pitch shifts in voice feedback. Analysis of ERPs showed that the amplitudes of the N1 and P2 components were significantly reduced in response to predictable compared with unpredictable stimuli. These findings indicate that predictions about temporal features of sensory feedback can modulate vocal motor behavior. In the context of the predictive coding model, temporally-predictable stimuli are learned and reinforced by the internal feedforward system, and as indexed by the ERP suppression, the sensory feedback contribution is reduced for their processing. These findings provide new insights into the neural mechanisms of vocal production and motor control.