Changes in human papillomavirus typing of recurrent respiratory papillomatosis progressing to malignant neoplasm.

Changes in human papillomavirus typing of recurrent respiratory papillomatosis progressing to malignant neoplasm.
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复发性呼吸道乳头状瘤病进展为恶性肿瘤的人乳头瘤病毒分型的变化。

DOI:
10.1001/archotol.1994.01880350079014
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发表时间:
1994
期刊:
Archives of otolaryngology--head & neck surgery
影响因子:
--
通讯作者:
Robert H. Miller
Robert H. Miller
中科院分区:
--
文献类型:
--
作者:
Deborah J. Doyle;Lee A. Henderson;Francis E. LeJeune;Robert H. Miller

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一名患有复发性呼吸道乳头状瘤病的患者自发进展为癌症并导致死亡。通过聚合酶链反应和 Southern 杂交检测该患者 9 年病程中获得的连续活检标本,以检测患者病程中存在的人乳头瘤病毒 (HPV) 类型。早期活检标本的 HPV 6 型和 11 型呈阳性。随着异型性进展为癌,HPV 6 型和 11 型仍然存在,但信号减弱,HPV 16 变得越来越阳性。将讨论这些发现的意义。
A patient with recurrent respiratory papillomatosis progressed spontaneously to carcinoma resulting in death. Serial biopsy specimens obtained during a 9-year course of this patient's disease were tested via polymerase-chain reaction and Southern hybridization to detect the human papillomavirus (HPV) types present during the patient's course of disease. Early biopsy specimens were positive for HPV types 6 and 11. As atypia progressed to carcinoma, HPV types 6 and 11 remained present, but the signal decreased and HPV 16 became increasingly positive. The significance of these findings will be discussed.
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