New facile enantio- and diastereo-selective syntheses of (-)-triptonide and (-)-triptolide
New facile enantio- and diastereo-selective syntheses of (-)-triptonide and (-)-triptolide
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(-)-雷公藤内酯和(-)-雷公藤内酯酯的新的简易对映和非对映选择性合成
DOI：
10.1039/c3ob42183j
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发表时间：
2014
影响因子：
3.2
通讯作者：
Li Chunxin
中科院分区：
文献类型：
--
作者：
Zhang Hongrui;Li Haifeng;Xue Jijun;Chen Rui;Li Ying;Tang Yu;Li Chunxin
通过两条合成路线分别以13.6%的总收率和18.5%的总收率完成了（-）-雷公藤内酯酮和（-）-雷公藤内酯醇的不对称合成，并以一种新的途径得到了它们的关键中间体4。这种合成是可扩展的，因此具有很高的应用潜力，以进一步合成精细化和生物学研究等天然产物。
A novel formal asymmetric synthesis of (−)-triptonide and (−)-triptolide, featuring a new alternative access to their known key intermediate 4, has been achieved through two synthetic routes in 9 steps with 13.6% total yield and 10 steps with 18.5% overall yield, respectively. This synthesis is scalable and hence has high potential for application to further synthetic elaboration and biologic investigation on such natural products.