Variation in global DNA hydroxymethylation with age associated with schizophrenia
Variation in global DNA hydroxymethylation with age associated with schizophrenia
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与精神分裂症相关的整体 DNA 羟甲基化随年龄的变化
DOI：
10.1016/j.psychres.2017.08.022
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发表时间：
2017-11-01
影响因子：
11.3
通讯作者：
Zhao, Cunyou
中科院分区：
文献类型：
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作者：
Jiang, Tingyun;Zong, Lu;Zhao, Cunyou
为了加深对精神分裂症发展过程中 DNA 羟甲基化 (5hmC) 和甲基化 (5mC) 的了解，本研究检测了 264 名精神分裂症患者和 221 名对照者外周血 DNA 中的整体 5hmC 和 5mC 水平，观察到与对照相比，患者中 5mC 水平升高，男性患者中 5hmC 水平升高，但女性患者中水平降低。 5mC水平与年龄呈性别依赖性正相关，5hmC水平在对照组中与年龄呈正相关，但在患者中呈负相关，其在精神分裂症发病机制中的作用仍有待阐明。
To improve understanding of DNA hydroxymethylation (5hmC) and methylation (5mC) in the development of schizophrenia, this study examined global 5hmC and 5mC levels in peripheral blood DNA of 264 patients with schizophrenia and 221 controls and observed increased 5mC levels in the patients and increased 5hmC levels in male patients but decreased levels in female patients as compared with the controls. The 5mC level displayed a gender-dependent positive correlation with age and the 5hmC level displayed a correlation with age positively in controls but negatively in patients, and their role in the pathogenesis of schizophrenia remains to be elucidated.