FACILITATORY AND INHIBITORY EFFECTS OF ELECTROCHEMICAL STIMULATION OF AMYGDALA ON RELEASE OF LUTEINIZING-HORMONE
FACILITATORY AND INHIBITORY EFFECTS OF ELECTROCHEMICAL STIMULATION OF AMYGDALA ON RELEASE OF LUTEINIZING-HORMONE
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DOI：
10.1016/0006-8993(78)90437-7
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发表时间：
1978-01-01
期刊：
影响因子：
2.9
通讯作者：
TALEISNIK, S
中科院分区：
文献类型：
--
作者：
BELTRAMINO, C;TALEISNIK, S
在未麻醉、不受约束的大鼠中研究了刺激杏仁核对促黄体生成素（LH）释放的影响。在11.30 h时通过慢性植入不同杏仁核的不锈钢电极施加电化学刺激（阳极DC）;内侧（Men.），皮质（Con.），中央（Cn.），或基底外侧（Bln.）。在实验程序的不同时间，使用插入颈静脉的塑料插管采集血样。在发情前期的大鼠中，刺激（100 μ A/30 s）Bln.导致自发排卵和排卵前LH释放的阻断，以及Cn。导致荷尔蒙分泌延迟相反，男人的刺激。有效地提前了正常LH峰的时间，而在男性中应用的切除卵巢的雌激素致敏大鼠的Con.刺激（100 μ A/60 s）没有发生正常模式的变化。或Con.诱导的LH释放，而Bln.或Cn。没有效果。男性释放LH。刺激和Bln的阻断作用。显示出与输送的电流量的密切关系。抑制比激活所需的阈值低。刺激诱发男性LH释放。无论是在8.30 h、11.30 h还是14.00 h，去卵巢雌激素致敏大鼠的海马神经元均在一天的同一时间发生，表明杏仁核具有调节作用。刺激后，未观察到血清LH浓度的变化。去势雌激素致敏雄性大鼠或Bln.卵巢切除的非致敏大鼠。杏仁核对LH、Bln的释放有双重作用。被抑制和男人。便利的。
The effect of amygdaloid stimulation on the release of luteinizing hormone (LH) was studied in unanesthetized, unrestrained rats. Electrochemical stimulation (anodic DC) was applied at 11.30 h through stainless steel electrodes chronically implanted into different amygdaloid nuclei; medial (Men.), cortical (Con.), central (Cn.), or basolateral (Bln.). A plastic cannula inserted into the jugular vein was used for obtaining blood samples at different times of the experimental procedure. In rats on the day of proestrus, stimulation (100 .mu.A/30 s) in the Bln. resulted in blockade of spontaneous ovulation and of the preovulatory LH release, and that in the Cn. produced a delay in the hormone discharge. On the contrary, stimulation in the Men. was effective in advancing the time of the normal LH surge, while no change of the normal pattern occurred from the Con. Stimulation (100 .mu.A/60 s) of ovariectomized estrogen-primed rats applied in the Men. or the Con. induced LH release, while that in the Bln. or the Cn. had no effect. The release of LH by Men. stimulation and the blocking effect of Bln. showed a close relationship with the amount of current delivered. Lower thresholds were required for inhibition than for activation. The release of LH induced by stimulation in the Men. of ovariectomized estrogen-primed rats occurred at the same time of the day whether the stimulus was applied at 8.30 h, 11.30 h or 14.00 h, indicating a modulatory effect of the amygdala. No changes in serum LH concentration were observed after stimulation of the Men. of castrated estrogen-primed male rats or in the Bln. of ovariectomized non-primed rats. The amygdala exerts a dual effect on the release of LH, the Bln. being inhibitory and the Men. and Con. facilitatory.