Using γ-Ray Polymerization-Induced Assemblies to Synthesize Polydopamine Nanocapsules
Using γ-Ray Polymerization-Induced Assemblies to Synthesize Polydopamine Nanocapsules
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DOI：
10.3390/polym11111754
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发表时间：
2019-10
期刊：
影响因子：
5
通讯作者：
Wenwen Jiang;Xinyue Zhang;Yafei Luan;Ren-Sheng Wang;Hanzhou Liu;Dan Li;Liang Hu
中科院分区：
文献类型：
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作者：
Wenwen Jiang;Xinyue Zhang;Yafei Luan;Ren-Sheng Wang;Hanzhou Liu;Dan Li;Liang Hu
这项工作报告了一种简单而稳健的聚多巴胺纳米胶囊（PDA NC）合成策略。首先，在不存在任何表面活性剂的情况下，通过 γ 射线诱导液-液（H2O-丙烯酸酯）界面聚合策略合成聚合物组件。 1H核磁共振分析和分子动力学模拟表明，聚合物组装体的生成很大程度上取决于丙烯酸酯的亲水性和界面处低聚物的重力。利用聚合物组件的球形结构和机械稳定性，接下来通过多巴胺在组件上的界面聚合，然后使用乙醇去除模板来制备PDA NC。聚多巴胺纳米胶囊可负载和释放环丙沙星（CIP，一种模型药物），因此负载 CIP 的 PDA NC 能够抑制大肠杆菌的生长。
This work reports a simple and robust strategy for synthesis of polydopamine nanocapsules (PDA NCs). First, polymer assemblies were synthesized by a γ-ray-induced liquid–liquid (H2O–acrylate) interface polymerization strategy, in the absence of any surfactants. 1H nuclear magnetic resonance analysis and molecular dynamics simulation reveal that the generation of polymer assemblies largely depends on the hydrophilicity of acrylate and gravity of the oligomers at the interface. By virtue of the spherical structure and mechanic stability of the polymer assemblies, PDA NCs are next prepared by the interfacial polymerization of dopamine onto the assemblies, followed by the removal of templates by using ethanol. The polydopamine nanocapsules are shown to load and release ciprofloxacin (CIP, a model drug), such that the CIP-loaded PDA NCs are able to inhibit the growth of Escherichia coli.