Nullomers: really a matter of natural selection?
Nullomers: really a matter of natural selection?
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DOI：
10.1371/journal.pone.0001022
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发表时间：
2007-10-10
期刊：
影响因子：
3.7
通讯作者：
Kumar, Sudhir
中科院分区：
文献类型：
--
作者：
Acquisti, Claudia;Poste, George;Curtiss, David;Kumar, Sudhir
零片段是人类和其他物种基因组中不存在的短DNA序列。假设零分子是针对人类有害序列的自然选择的特征，那么零分子在药物靶标识别、农药开发、环境监测和法医应用中的应用已经被设想。在这里，我们表明CpG二核苷酸的高易变性，而不是针对零序序列的自然选择，可能是短序列基序成为零序的现象事件的原因。此外，许多报道的人类零配体只有一个核苷酸不同，这加强了突变在种群和物种中零配体群进化中的作用。黑猩猩、牛、狗和老鼠基因组中已知的零染色体显示出与人类基因组一致的模式。突变的作用，而不是选择的作用，在产生零子的过程中，使人们对零子在许多设想的应用中的效用产生了怀疑，因为它们依赖于致死选择对零子起源的作用。
Nullomers are short DNA sequences that are absent from the genomes of humans and other species. Assuming that nullomers are the signatures of natural selection against deleterious sequences in humans, the use of nullomers in drug target identification, pesticide development, environmental monitoring, and forensic applications has been envisioned. Here, we show that the hypermutability of CpG dinucleotides, rather than the natural selection against the nullomer sequences, is likely the reason for the phenomenal event of short sequence motifs becoming nullomers. Furthermore, many reported human nullomers differ by only one nucleotide, which reinforces the role of mutation in the evolution of the constellation of nullomers in populations and species. The known nullomers in chimpanzee, cow, dog, and mouse genomes show patterns that are consistent with those seen in humans. The role of mutations, instead of selection, in generating nullomers cast doubt on the utility of nullomers in many envisioned applications, because of their dependence on the role of lethal selection on the origin of nullomers.
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作者：
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