Efficacy of Treatment for Patients With Achalasia Depends on the Distensibility of the Esophagogastric Junction
Efficacy of Treatment for Patients With Achalasia Depends on the Distensibility of the Esophagogastric Junction
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DOI：
10.1053/j.gastro.2012.04.048
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发表时间：
2012-08-01
期刊：
影响因子：
29.4
通讯作者：
Boeckxstaens, Guy E.
中科院分区：
文献类型：
--
作者：
Rohof, Wout O.;Hirsch, David P.;Boeckxstaens, Guy E.
背景与目的：许多治疗后持续性吞咽困难和反流的患者下食管括约肌（LES）压力较低或无压力。食管胃连接处（EGJ）的扩张性很大程度上决定了食管排空。我们研究了 EGJ 扩张性的评估是否是比 LES 压力更好、更综合的参数，用于确定贲门失弛缓症患者的治疗效果。方法：我们使用内窥镜功能性管腔成像探针 (EndoFLIP) 测量了 15 名健康志愿者（对照组；8 名男性；年龄，40 +/- 4.1 岁）和 30 名贲门失弛缓症患者（16 名男性；年龄，51 +/- 3.1 岁）的 EGJ 扩张性。还通过食管测压和定时食管钡餐造影对患者进行评估。使用 Eckardt 评分评估症状评分，评分
BACKGROUND & AIMS: Many patients with persistent dysphagia and regurgitation after therapy have low or no lower esophageal sphincter (LES) pressure. Distensibility of the esophagogastric junction (EGJ) largely determines esophageal emptying. We investigated whether assessment of the distensibility of the EGJ is a better and more integrated parameter than LES pressure for determining efficacy of treatment for patients with achalasia. METHODS: We measured distensibility of the EGJ using an endoscopic functional luminal imaging probe (EndoFLIP) in 15 healthy volunteers (controls; 8 male; age, 40 +/- 4.1 years) and 30 patients with achalasia (16 male; age, 51 +/- 3.1 years). Patients were also assessed by esophageal manometry and a timed barium esophagogram. Symptom scores were assessed using the Eckardt score, with a score