Circulating basophil count as a prognostic marker of tumor aggressiveness and survival outcomes in colorectal cancer
Circulating basophil count as a prognostic marker of tumor aggressiveness and survival outcomes in colorectal cancer
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循环嗜碱性粒细胞计数作为结直肠癌肿瘤侵袭性和生存结果的预后标志物
DOI：
10.1186/s40169-019-0255-4
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发表时间：
2020-02-10
影响因子：
10.6
通讯作者：
Li, Xinxiang
中科院分区：
文献类型：
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作者：
Liu, Qi;Luo, Dakui;Li, Xinxiang
背景越来越多的证据表明，嗜碱性粒细胞在影响肿瘤周围组织微环境中具有免疫/炎症相关的意义，本研究旨在阐明血清嗜碱性粒细胞计数水平的临床价值。生存曲线采用Kaplan-Meier法。建立了几个COX比例风险模型来评估预后因素。结果术前嗜碱粒细胞计数和 0.025*10 9/L与高T分期、高N分期、静脉侵犯、神经侵犯、血清CEA水平升高及预后不良密切相关(P<0.0 5，P<0.0 5)。多因素COX分析显示，术前嗜碱粒细胞计数低的患者的无瘤生存率明显降低[危险比(HR) = 为2.197，95%CI为1.868~2.585]。结论术前血嗜碱性粒细胞计数低是一种常见的免疫/炎症相关生物标志物，与肿瘤侵袭性有关，预后不良。术前血清嗜碱粒细胞计数可作为判断结直肠癌患者预后的一项有用而简便的指标。
AbstractBackgroundAccumulating evidence demonstrated immune/inflammation‐related implications of basophils in affecting tissue microenvironment that surrounded a tumor, and this study aimed to elucidate the clinical value of serum basophil count level.MethodsBetween December 2007 and September 2013, 1029 patients diagnosed with stage I–III CRC in Fudan University Shanghai Cancer Center meeting the essential criteria were identified. The Kaplan–Meier method was used to construct the survival curves. Several Cox proportional hazard models were constructed to assess the prognostic factors. A simple predictor (CB classifier) was generated by combining serum basophil count and serum carcinoembryonic antigen (CEA) level which had long been accepted as the most important and reliable prognostic factor in CRC.ResultsThe preoperative basophils count < 0.025*109/L was strongly associated with higher T stage, higher N stage, venous invasion, perineural invasion, elevated serum CEA level, and thus poor survival (P < 0.05). Moreover, multivariate Cox analysis showed that patients with low level of preoperative basophils count had an evidently poorer DFS [Hazard ratio (HR) = 2.197, 95% CI 1.868–2.585].ConclusionsAs a common immune/inflammation‐related biomarker available from the blood routine examination, low level of preoperative serum basophil count was associated with aggressive biology and indicated evidently poor survival. Preoperative serum basophil count would be a useful and simple marker for the management of CRC patients.