State of the art in tumor antigen and biomarker discovery.
State of the art in tumor antigen and biomarker discovery.
复制标题
DOI：
10.3390/cancers3022554
复制
发表时间：
2011-06-09
期刊：
影响因子：
5.2
通讯作者：
Chames, Patrick
中科院分区：
文献类型：
--
作者：
Even-Desrumeaux, Klervi;Baty, Daniel;Chames, Patrick
我们对肿瘤免疫学的了解导致了多种治疗癌症的方法。然而，新肿瘤标志物的研究与免疫疗法的发展之间存在差距，可用于治疗的标志物很少。现在的挑战是发现主动和被动免疫疗法的新靶点。本综述旨在描述生物标志物和肿瘤抗原发现在抗原性质和定位方面的最新进展，并重点介绍用于其发现的最新方法，包括“组学”技术。
Our knowledge of tumor immunology has resulted in multiple approaches for the treatment of cancer. However, a gap between research of new tumors markers and development of immunotherapy has been established and very few markers exist that can be used for treatment. The challenge is now to discover new targets for active and passive immunotherapy. This review aims at describing recent advances in biomarkers and tumor antigen discovery in terms of antigen nature and localization, and is highlighting the most recent approaches used for their discovery including "omics" technology.