The Relationship Between Serum Selenium Concentration and Neutrophil Function in Peripheral Blood
The Relationship Between Serum Selenium Concentration and Neutrophil Function in Peripheral Blood
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DOI：
10.1007/s12011-011-9108-8
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发表时间：
2011-12-01
影响因子：
3.9
通讯作者：
Nakaji, Shigeyuki
中科院分区：
文献类型：
--
作者：
Lee, Sangun;Takahashi, Ippei;Nakaji, Shigeyuki
我们评估了一般人群中嗜酸性粒细胞相关功能与血清硒（Se）浓度之间的关系。我们检查了800名参加2005年岩城健康促进项目的受试者，以确定血清硒浓度与嗜酸性粒细胞相关功能之间的关系，如活性氧（ROS）的产生能力，吞噬活性和血清调理活性（SOA）。在未受刺激的中性粒细胞中，即，在中性粒细胞中，在应用吞噬刺激之前处于其基线条件下，血清Se浓度趋于高而ROS产生趋于低。在SOA方面，光泽精依赖的化学发光与男性和女性的血清硒浓度呈显著负相关。此外，在女性中，鲁米诺依赖的化学发光和血清硒浓度之间观察到显着的负相关。这些结果表明，血清硒浓度较低的受试者可能会暴露于更大的慢性氧化应激，由于中性粒细胞ROS的生产。此外，我们的研究结果表明，女性而不是男性从硒中受益更多，以对抗氧化应激。
We evaluated the relationships between neutrophil-related functions and serum selenium (Se) concentration in the general population. We examined 800 subjects who had participated in the Iwaki Health Promotion Project in 2005 to determine the relationships between serum Se concentration and neutrophil-related functions such as the production capability of reactive oxygen species (ROS), phagocytic activity, and serum opsonic activity (SOA). In nonstimulated neutrophils, i.e., in neutrophils at their baseline condition before the application of the phagocytic stimulus, the serum Se concentration tends to be high and the ROS production tends to be low. With regard to SOA, there was a significant negative correlation between lucigenin-dependent chemiluminescence and serum Se concentration in both men and women. Moreover, in women, a significant negative correlation was observed between luminol-dependent chemiluminescence and serum Se concentration. These results suggest that subjects with a lower serum Se concentration may be exposed to a greater chronic oxidative stress due to neutrophil ROS production. In addition, the findings of our study suggest that women rather than men benefit more from Se against oxidative stress.