Protein structural transitions and their functional role
Protein structural transitions and their functional role
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DOI：
10.1098/rsta.2004.1496
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发表时间：
2005-02-15
期刊：
影响因子：
5
通讯作者：
Yang, W
中科院分区：
文献类型：
--
作者：
Karplus, M;Gao, YQ;Yang, W
活细胞是分子机器的集合，它们执行细胞存在、分化和繁殖所必需的许多功能。这些机器中的大多数（尽管不是全部）都是由蛋白质组成的。由于它们的复杂性，了解它们的工作原理需要实验和理论研究的协同结合。在本文中，我们概述了对两种此类蛋白质机器的研究。一种是 GroEL，来自大肠杆菌的分子伴侣，有助于蛋白质折叠；另一个是F-1-ATPase，一种合成和水解ATP的运动蛋白。
Living cells are a collection of molecular machines which carry out many of the functions essential for the cell's existence, differentiation and reproduction. Most, though not all, of these machines are made up of proteins. Because of their complexity, an understanding of how they work requires a synergistic combination of experimental and theoretical studies. In this paper we outline our studies of two such protein machines. One is GroEL, the chaperone from Escherichia coli, which aids in protein folding; the other is F-1-ATPase, a motor protein which synthesizes and hydrolyses ATP.